Atividade antifúngica na espécie Murraya paniculata (L.) Jack - uma revisão sistemática de literatura
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Data
2021-05-28
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Universidade Federal de Goiás
Resumo
Yeast infections affect millions of people annually, especially immunocompromised patients. The existing treatment, although effective, presents problems such as the risk of causing toxicity, and the generation of fungal strains resistant to medicine drugs. Therefore, there is a need for new compounds capable of treating fungal infections more safely and effectively, and natural products become a viable alternative. The products of plant origin have a high molecular variety in their metabolites and are widely used in the search for new bioactive molecules. In this context, Murraya paniculata (L.) Jack, is a possible source of active molecules. The objective of this work was to make a systematic bibliographic review to verify the antifungal activity of extracts and essential oils obtained from Murraya paniculata. Six articles related to the subject matter were found and the studies demonstrate antifungal potential both of extracts obtained from leaves and of essential oils, with emphasis on the compound β-Caryophyllene, being one of those responsible for the antimicrobial action. Using the in vitro methodology, the following fungi were tested: Aspergillus flavus, A. fumigatus, A. niger, A. parasiticus, Candida albicans, Cryptococcus neoformans, Fusarium solani and Microsporum gypseum, and it was found that although there is an antifungal potential for M. paniculata, more specific studies are needed regarding the molecule responsible for antifungal activity, as well as the purification of compounds from the extracts obtained.
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Palavras-chave
Antimicrobiano, Óleo essencial, Candida albicans, Infecções fúngicas invasivas, Produtos naturais, Antimicrobial, Essential oil, Invasive fungal infections, Natural products
Citação
SANTOS, Carine Fernandes dos; SOUZA, Warlles Filgueira. Atividade antifúngica na espécie Murraya paniculata (L.) Jack - uma revisão sistemática de literatura. 2021. 25 f. Trabalho de Conclusão de Curso (Graduação) - Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, 2021.