In vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice

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dc.creatorTurner, Joanne
dc.creatorGonzalez Juarrero, Mercedes
dc.creatorEllis, Debi L.
dc.creatorBasaraba, Randy J.
dc.creatorKipnis, Andre
dc.creatorOrme, Ian M.
dc.creatorCooper, Andrea M.
dc.date.accessioned2021-02-11T12:25:44Z
dc.date.available2021-02-11T12:25:44Z
dc.date.issued2002
dc.description.abstractThe production of immunosuppressive cytokines, such as IL-10 and TGF- , has been documented in individuals diagnosed with active tuberculosis. In addition, IL-10 production is increased within the lungs of mice that have chronic mycobacterial infection. Therefore, we hypothesized that the down-regulatory properties of IL-10 might contribute to the reactivation of chronic Mycobacterium tuberculosis infection in mice. To determine the influence of IL-10 on the course of infection, transgenic mice producing increased amounts of IL-10 under the control of the IL-2 promotor were infected with M. tuberculosis via the respiratory route. Mice that overexpressed IL-10 showed no increase in susceptibility during the early stages of infection, but during the chronic phase of the infection showed evidence of reactivation tuberculosis with a highly significant increase in bacterial numbers within the lungs. Reactivation was associated with the formation of macrophage-dominated lesions, decreased mRNA production for TNF and IL-12p40, and a decrease in Ag-specific IFN- secretion. These data support the hypothesis that IL-10 plays a pivotal role during the chronic/latent stage of pulmonary tuberculosis, with increased production playing a potentially central role in promoting reactivation tuberculosis.pt_BR
dc.identifier.citationTURNER, Joanne et al. In vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. The Journal of Immunology, Rockville, v. 169, n. 11, p. 6343-6351, 2002.pt_BR
dc.identifier.doi10.4049/jimmunol.169.11.6343
dc.identifier.issn0022-1767
dc.identifier.issne- 1550-6606
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/19352
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIn vivo il-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 micept_BR
dc.typeArtigopt_BR

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