Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

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dc.creatorCravo, Sergio Luiz Domingues
dc.creatorLopes, Oswaldo Ubríaco
dc.creatorPedrino, Gustavo Rodrigues
dc.date.accessioned2018-09-11T11:48:27Z
dc.date.available2018-09-11T11:48:27Z
dc.date.issued2011-09
dc.description.abstractWater deprivation and hypernatremia are major challenges for water and sodium homeostasis. Cellular integrity requires maintenance of water and sodium concentration within narrow limits. This regulation is obtained through engagement of mul- tiple mechanisms and neural pathways that regulate the volume and composition of the extracellular fluid. The purpose of this short review is to summarize the literature on central neural mechanisms underlying cardiovascular, hormonal and autonomic responses to circulating volume changes, and some of the findings obtained in the last 12 years by our laboratory. We review data on neural pathways that start with afferents in the carotid body that project to medullary relays in the nucleus tractus solitarii and caudal ventrolateral medulla, which in turn project to the median preoptic nucleus in the forebrain. We also review data sug- gesting that noradrenergic A1 cells in the caudal ventrolateral medulla represent an essential link in neural pathways controlling extracellular fluid volume and renal sodium excretion. Finally, recent data from our laboratory suggest that these structures may also be involved in the beneficial effects of intravenous infusion of hypertonic saline on recovery from hemorrhagic shock.pt_BR
dc.identifier.citationCRAVO, S. L.; LOPES, O. U.; PEDRINO, G. R. Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 44, n. 9, p. 877-882, Sept. 2011.pt_BR
dc.identifier.doi10.1590/S0100-879X2011007500092 
dc.identifier.issne- 1414-431X
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15899
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBaroreceptorspt_BR
dc.subjectBlood pressurept_BR
dc.subjectA1 noradrenergic neuronspt_BR
dc.subjectHypertonic salinept_BR
dc.subjectAV3Vpt_BR
dc.subjectRenal vascular conductancept_BR
dc.titleInvolvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volumept_BR
dc.typeArtigopt_BR

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