Expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasia

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dc.creatorSantos, Silvia Helena Rabelo dos
dc.creatorAndrade, Liliana Aparecida Lucci Angelo
dc.creatorDerchain, Sophie
dc.creatorPinto, Glauce Aparecida
dc.creatorMorais, Sirlei Siani
dc.creatorLatuf Filho, Paulo Latuf
dc.date.accessioned2020-09-25T16:21:21Z
dc.date.available2020-09-25T16:21:21Z
dc.date.issued2015-01
dc.description.abstractAbstract Aim: To evaluate the expression of MMP-2, MMP-9, MMP-14, TIMP-1 and TIMP-2 in Cervical intraepithelial neoplasia grade 3 (CIN 3) and invasive squamous cell carcinoma. Methods and Results: This study comprised three groups: Group 1: 55 cases with CIN 3; Group 2: 30 cases with CIN 3 and invasive carcinoma components; Group 3: 46 cases with invasive carcinoma. Protein expression was investigated in tumor and stromal cells by immunohistochemistry and percentages of immunostained cells were determined. The mean percentage of MMP-14 tumor cells was significantly higher in stromal cells in all groups. TIMP-2 and MMP-9 expression was significantly higher in stromal cells than in tumor cells. TIMP-1 had a significantly higher expression in stromal cells of carcinoma and tumor cells of CIN 3. Stromal cells expression of MMP-2, MMP14, TIMP-1 was increased with the severity of cervical neoplasia. The expression of MMP-2 in stromal cells that was higher in CIN 3 component of Group 2 than in CIN 3 of Group 1. Conclusions: The increase in MMP-2 expression from CIN 3 to invasive cervical cancer reinforces their role in cervical cancer progression. From CIN 3 to invasive cervical carcinoma, TIMP-1 expression increased in stromal cells and decreased in tumor cells.pt_BR
dc.identifier.citationESTIN, Maria Cristina do Amaral et al. Expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasia. Journal of cytology and histology, Brussels, v. 2, nesp, p. 2-5, Jan. 2015.pt_BR
dc.identifier.doi10.4172/2157-7099.S3-019
dc.identifier.issn2157-7099
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/19097
dc.language.isoengpt_BR
dc.publisher.countryBelgicapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saude Publica - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectMatrix metalloproteinasept_BR
dc.subjectTissue inhibitor of metalloproteinasespt_BR
dc.subjectCervical intraepithelial neoplasiapt_BR
dc.subjectUterine cervical neoplasmspt_BR
dc.subjectNeoplasm invasivenesspt_BR
dc.subjectCarcinogenesispt_BR
dc.titleExpression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 in intraepithelial and invasive cervical neoplasiapt_BR
dc.typeArtigopt_BR

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