Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals

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dc.creatorFerreira, Mônica Spadafora
dc.creatorFernandes, Luciana Caetano
dc.creatorPfrimer, Irmtraut Araci Hoffmann
dc.creatorPichiteli, Cássia Regina
dc.creatorTambourgi, Denise Vilarinho
dc.creatorLino Junior, Ruy de Souza
dc.creatorCarvalhaes, Mara Silvia
dc.date.accessioned2018-08-13T12:18:49Z
dc.date.available2018-08-13T12:18:49Z
dc.date.issued2010
dc.description.abstractRecently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental lagochilascariosis in H-2 a identical B10.A and A/J mice. Infected B10.A mice had a lower survival ratio and more severe lesions in the lungs than did A/J mice. Splenocytes of A/J mice immunized with the crude extract of the parasite showed increased proliferation and produced a higher level of interleukin 10 and interferon-γ in the presence of CE or concanavalin A when compared to B10.A mice. This suggests that resistance of A/J mice may be due to less severe lesions in lungs and other organs and a better immune response to parasite antigens. This paper provides evidence that major histocompatibility complex haplotype does not influence the survival to experimental infection with L. minor.pt_BR
dc.identifier.citationSPADAFORA-FERREIRA, Mônica; FERNANDES, Luciana Caetano; PFRIMER, Irmtraut Araci Hoffman; PICHITELI, Cássia Regina; TAMBOURGI, Denise Vilarinho; LINO-JUNIOR, Ruy de Souza; CARVALHAES, Mara Silvia. Lagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animals. Journal of Parasitology Research, London, v. 2010, p. 1-9, 2010.pt_BR
dc.identifier.doi10.1155/2010/610457
dc.identifier.issn2090-0023
dc.identifier.issne- 2090-0031
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15584
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleLagochilascaris minor: susceptibility and resistance to experimental infection in mice is independent of H-2a haplotype and correlates with the immune response in immunized animalspt_BR
dc.typeArtigopt_BR

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