Catecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses

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dc.creatorOliveira, André Henrique Freiria de
dc.creatorBlanch, Graziela Torres
dc.creatorPedrino, Gustavo Rodrigues
dc.creatorCravo, Sergio Luiz Domingues
dc.creatorMurphy, David
dc.creatorMenani, Jose Vanderlei
dc.creatorColombari, Débora Simões de Almeida
dc.date.accessioned2021-01-08T13:29:38Z
dc.date.available2021-01-08T13:29:38Z
dc.date.issued2015
dc.description.abstractCatecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses. Am J Physiol Regul Integr Comp Physiol 309: R1082–R1091, 2015. First published September 2, 2015; doi:10.1152/ajpregu.00432.2014.—Noradrenergic A2 neurons of the nucleus of the solitary tract (NTS) have been suggested to con tribute to body fluid homeostasis and cardiovascular regulation. In the present study, we investigated the effects of lesions of A2 neurons of the commissural NTS (cNTS) on the c-Fos expression in neurons of the hypothalamic paraventricular (PVN) and su praoptic (SON) nuclei, arterial pressure, water intake, and urinary excretion in rats with plasma hyperosmolality produced by intra gastric 2 M NaCl (2 ml/rat). Male Holtzman rats (280 –320 g) received an injection of anti-dopamine- -hydroxylase-saporin (12.6 ng/60 nl; cNTS/A2-lesion, n 28) or immunoglobulin G (IgG)-saporin (12.6 ng/60 nl; sham, n 24) into the cNTS. The cNTS/A2 lesions increased the number of neurons expressing c-Fos in the magnocellular PVN in rats treated with hypertonic NaCl (90 13, vs. sham: 47 20; n 4), without changing the number of neurons expressing c-Fos in the parvocellular PVN or in the SON. Contrary to sham rats, intragastric 2 M NaCl also increased arterial pressure in cNTS/A2-lesioned rats (16 3, vs. sham: 2 2 mmHg 60 min after the intragastric load; n 9), an effect blocked by the pretreatment with the vasopressin antagonist Manning compound (0 3 mmHg; n 10). In addition, cNTS/A2 lesions enhanced hyperosmolality-induced water intake (10.5 1.4, vs. sham: 7.7 0.8 ml/60 min; n 8 –10), without changing renal responses to hyperosmolality. The results suggest that inhib itory mechanisms dependent on cNTS/A2 neurons reduce water intake and vasopressin-dependent pressor response to an acute increase in plasma osmolality.pt_BR
dc.identifier.citationFREIRIA-OLIVEIRA, Andre H. et al. Catecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responses. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Rockville, v. 309, n. 9, p. R1082-R1091, 2015.pt_BR
dc.identifier.doi10.1152/ajpregu.00432.2014
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/19289
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectc-Fos expressionpt_BR
dc.subjectOsmoreceptorpt_BR
dc.subjectBlood pressurept_BR
dc.subjectVasopressinpt_BR
dc.subjectThirstpt_BR
dc.titleCatecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responsespt_BR
dc.typeArtigopt_BR

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