Genetic diversity of PspA types among nasopharyngeal isolates collected during an ongoing surveillance study of children in Brazil

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dc.creatorPimenta, Fabiana Cristina
dc.creatorDias, Fátima Ribeiro
dc.creatorBrandileone, Maria Cristina de Cunto
dc.creatorMiyaji, Eliane Namie
dc.creatorLeite, Luciana Cezar de Cerqueira
dc.creatorAndrade, Ana Lúcia Sampaio Sgambatti de
dc.date.accessioned2018-06-27T12:58:48Z
dc.date.available2018-06-27T12:58:48Z
dc.date.issued2006-08
dc.description.abstractPneumococcal surface protein A (PspA) has been considered a potential candidate for human vaccines because of its serotype-independent protective immunity. Nasopharyngeal (NP) pneumococcal colonization is highly prevalent in infants and precedes the invasive disease. Thus, prevention of NP colonization may reduce the burden of pneumococcal disease in children. Scarce information focusing on PspA from pneumococcal carriage in humans is available. We examined the genetic diversity of PspA from NP isolates obtained during an ongoing pneumococcal surveillance study with children. PspA families and clades of 183 communityacquired Streptococcus pneumoniae NP isolates from healthy children (n 97) and children with respiratory tract infections (n 48), pneumonia (n 33), or meningitis (n 5) were investigated. Overall, 79.8% (n 146) of the pneumococcal isolates were classified as PspA family 1 (35.5%) and family 2 (44.3%), whereas 20.2% of the isolates could not be typed. The distribution of PspA families and clades did not differ significantly according to the clinical status of the children. A dendrogram comparing the genetic relationship between the amino acid sequences of the clade-defining region of PspA from NP strains together with 24 invasive reference strains (GenBank) closely reproduced the profile of the families and clades previously reported for pneumococcal invasive strains. These findings strengthen the idea that the use of PspA as a vaccine antigen may protect children against carriage as well as invasive pneumococcal disease.pt_BR
dc.identifier.citationPIMENTA, Fabiana Cristina et. al. Genetic diversity of PspA types among nasopharyngeal isolates collected during an ongoing surveillance study of children in Brazil. Journal of Clinical Microbiology, Washington, v. 44, n. 8, p. 2838-2843, 2006.pt_BR
dc.identifier.doi10.1128/JCM.00156-06
dc.identifier.issn0095-1137
dc.identifier.issne-1098-660X
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15314
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleGenetic diversity of PspA types among nasopharyngeal isolates collected during an ongoing surveillance study of children in Brazilpt_BR
dc.typeArtigopt_BR

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