Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractions

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dc.creatorOliveira, Rodrigo Borges de
dc.creatorNascimento, Marcus Vinícius Mariano
dc.creatorCarvalho, Adryano Augustto Valladão de
dc.creatorValadares, Marize Campos
dc.creatorPaula, José Realino de
dc.creatorCosta, Elson Alves
dc.creatorCunha, Luiz Carlos da
dc.date.accessioned2018-09-26T15:53:54Z
dc.date.available2018-09-26T15:53:54Z
dc.date.issued2013
dc.description.abstractSynadenium umbellatum Pax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of in�ammation, pain, and several diseases. is study aimed to investigate the antinociceptive and anti-in�ammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail �ick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test. EES and MF reduced the number of acetic acid-induced abdominal writhes, while CF and HF did not. EES effect on acetic acid-induced abdominal writhing was reversed with a pretreatment with naloxone. EES reduced licking time in both phases of the formalin-induced paw licking test, but did not prolong the latency in the tail �ick test. ese results show that EES presented antinociceptive activity, probably involving the opioid system, anti-in�ammatory activity in the croton oil-induced ear edema test, and leukocyte migration into the intraperitoneal cavity. MF also presented anti-in�ammatory activity in the croton oil-induced ear edema test. In conclusion, EES and MF have antinociceptive activity involving the opioid system and anti-in�ammatory activity.pt_BR
dc.identifier.citationBORGES, Rodrigo et al. Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractions. Evidence-Based Complementary and Alternative Medicine, London, v. 2013, p. 1-9, 2013.pt_BR
dc.identifier.doi10.1155/2013/715650
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16057
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAntinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum pax. (euphorbiaceae) leaves and its fractionspt_BR
dc.typeArtigopt_BR

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