Acquired antiretroviral drug resistance mutations upon treatment failure in hiv-1 infected pediatric patients in central brazil

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dc.creatorAlbuquerque, Maly de
dc.creatorMarques, Solomar Martins
dc.creatorTeles-Filho, Ricardo Vieira
dc.creatorCosta, Paulo Sérgio Sucasas da
dc.date.accessioned2023-02-10T15:50:05Z
dc.date.available2023-02-10T15:50:05Z
dc.date.issued2020-09-09
dc.description.resumoAntiretroviral drug-resistance mutations compromise the successful treatment of children and adolescents infected with human immunodeficiency virus type 1 (HIV-1). We describe the clinical, virological, and immunological follow-up of a cohort of children and adolescents perinatally infected with HIV-1 treated at Hospital Estadual de Doenças Tropicais Dr. Anuar Auad – HDT, in Central Brazil, after therapeutic failure related to drug resistance mutations. We analyzed the results of the genotypic test (protease codons 1–99 and reverse transcriptase codons 1–325) performed from 2003 to 2015. The ARV susceptibility profile was analyzed according to Stanford HIV drug resistance database. A total of 65 patients (median age of 10 years; range, 18 m–18 y) with therapeutic failure (after a median of 55 months of follow up; range, 9 m–13 y) and plasma levels of HIV-1 RNA greater than 1,000 copies/mL which were included and demonstrated mutations in: nucleoside reverse transcriptase inhibitors (NRTIs), 98.5%; non nucleoside reverse transcriptase inhibitors (NNRTIs), 75.4%; and protease inhibitors (PI), 44.6%. The most frequent NRTI mutations were found in codon T215 (83.1%) with a predominance of T215Y (56.9%), followed by M184V (69.3%). In the NNRTI class, mutations K103N (36.9%) and 190A (23.1%) were predominant, and, in the protease, mutations 54VL (35.4%) and 82ASTL (32.3%) were found in approximately the same proportion, with a predominance of the M54V mutation. These results demonstrate the high levels of resistance to different classes of antiretrovirals in HIV-infected children and adolescents and the importance of genotypic resistance tests in this population.pt_BR
dc.identifier.citationALBUQUERQUE , Maly de; MARQUES, Solomar Martins; TELES FILHO, Ricardo Vieira; COSTA , Paulo Sucasas. Acquired antiretroviral drug resistance mutations upon treatment failure in hiv-1 infected pediatric patients in central brazil. Revista de Patologia Tropical, Goiânia, v. 49, n. 2, p. 79–93, apr./jun, 2020. DOI: 10.5216/rpt.v49i2.62639. Disponível em: https://revistas.ufg.br/iptsp/article/view/62639. Acesso em: 8 fev. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.5216/rpt.v49i2.62639
dc.identifier.issne - 1980-8178
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/21892
dc.language.isoengpt_BR
dc.publisherUniversidade Federal de Goiáspt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RMG)pt_BR
dc.publisher.initialsUFGpt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHIVpt_BR
dc.subjectDrug resistancept_BR
dc.subjectGenotypespt_BR
dc.subjectChildpt_BR
dc.subjectAdolescentpt_BR
dc.titleAcquired antiretroviral drug resistance mutations upon treatment failure in hiv-1 infected pediatric patients in central brazilpt_BR
dc.typeArtigopt_BR

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