Hepatitis B virus infection among institutionalized mentally ill patients in Brazil

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dc.creatorMoraes, Tatiane Cinquini
dc.creatorFiaccadori, Fabíola Souza
dc.creatorSouza, Menira Borges de Lima Dias e
dc.creatorAlmeida, Tâmera Nunes Vieira
dc.creatorCunha, Marielton dos Passos
dc.creatorCastro, Ítalo de Araújo
dc.creatorCardoso, Divina das Dôres de Paula
dc.date.accessioned2018-07-19T11:49:42Z
dc.date.available2018-07-19T11:49:42Z
dc.date.issued2015-12
dc.description.abstractObjectives: The main objective was to evaluate HBV infection and occult HBV infection (OBI) cases in mentally ill patients based on serological and molecular profiles. Material and methods: Serum samples of 333 long-stay mentally ill patients were tested for the prevalence of HBV markers by serological (ELISA) and molecular (PCR) assays. The PCR products were sequenced to determine viral genotypes. Results: It was observed a global prevalence of 12.9% (43/333) for HBV infection markers, considering HBsAg and/or anti-HBc positivity. Fourteen samples tested positive for anti-HBs alone. All samples positive (n = 57) for any HBV serological markers were tested for HBV-DNA and six were positive: HBsAg/anti-HBc (n = 1), anti-HBc/anti-HBs (n = 1), anti-HBs alone (n = 1), and anti-HBc alone (n = 3). The rate of OBI was 9.2% (5/54) from samples that were anti-HBc and/or anti-HBs positive. All sequenced samples were characterized as genotype A. Conclusion: The high rate of HBV infections found in this study suggests the possibility of HBV transmission due to risk factors displayed by some patients, and highlights the importance of vaccination of susceptible patients and the staff of that institution.pt_BR
dc.identifier.citationMORAES, Tatiane Cinquini; FIACCADORI, Fabíola Souza; SOUZA, Menira; ALMEIDA, Tâmera Nunes Vieira; CUNHA, Marielton dos Passos; CASTRO, Ítalo de Araújo; CARDOSO, Divina das Dôres de Paula. Hepatitis B virus infection among institutionalized mentally ill patients in Brazil. Brazilian Journal of Infectious Diseases, Salvador, v. 19, n. 6, p. 643-647, Nov./Dec. 2015.pt_BR
dc.identifier.doi10.1016/j.bjid.2015.07.007
dc.identifier.issn1413-867
dc.identifier.issne- 1678-4391
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15419
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHepatitis B viruspt_BR
dc.subjectOccult infectionpt_BR
dc.subjectPrevalencept_BR
dc.subjectMental illnesspt_BR
dc.titleHepatitis B virus infection among institutionalized mentally ill patients in Brazilpt_BR
dc.typeArtigopt_BR

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