Hypomethylation of tumor suppressor genes in odontogenic myxoma

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dc.creatorMoreira, Paula Rocha
dc.creatorCardoso, Fabiano Pereira
dc.creatorBrito, João Artur Ricieri
dc.creatorBatista, Aline Carvalho
dc.creatorGomes, Carolina Cavaliéri
dc.creatorGomez, Ricardo Santiago
dc.date.accessioned2018-10-25T13:54:06Z
dc.date.available2018-10-25T13:54:06Z
dc.date.issued2011
dc.description.abstractOdontogenic myxoma (OM) is an ectomesenchymal benign odontogenic tumor characterized by spindle or stellate-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. DNA methylation is characterized by the addition of methyl groups in cytosines within CpG islands in the promoter gene. DNA methylation can decrease the expression of tumor suppressor genes and contribute to the development of neoplastic lesions. The aim of study was to evaluate the methylation pattern of the tumor suppressor genes P16 (CDKN2A), P21 (CDKN1A), P27 (CDKN1B), P53 (TP53) and RB1 in OM and dental pulp. Methylation was evaluated using methylation-specific polymerase chain reaction (PCR). The transcription was studied in some cases by using reverse transcription quantitative PCR. A higher frequency of unmethylated P27, P53, and RB1 samples was observed in the OM when compared with the dental pulp. OM expressed mRNA of all the genes evaluated. Considering all the samples together, the expression of Rb was higher in the unmethylated samples compared with the partially methylated samples. This investigation revealed hypomethylation of the genes P27, P53, and RB1 in OM. In addition, methylation of tumor suppressor genes was found to be an usual event in normal dental pulp.pt_BR
dc.identifier.citationMOREIRA, Paula Rocha et al. Hypomethylation of tumor suppressor genes in odontogenic myxoma. Brazilian Dental Journal, Ribeirão Preto, v. 22, n. 5, p. 422-427, 2011.pt_BR
dc.identifier.doi10.1590/S0103-64402011000500013
dc.identifier.issn0103-6440
dc.identifier.issne- 1806-4760
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16246
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Odontologia - FO (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMethylationpt_BR
dc.subjectDental pulppt_BR
dc.subjectTumor suppressor genespt_BR
dc.subjectOdontogenic myxomapt_BR
dc.titleHypomethylation of tumor suppressor genes in odontogenic myxomapt_BR
dc.typeArtigopt_BR

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