Phytochemical analysis and antimicrobial, antinociceptive, and anti-inflammatory activities of two chemotypes of pimenta pseudocaryophyllus (Myrtaceae)

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dc.creatorPaula, Joelma Abadia Marciano de
dc.creatorSilva, Maria do Rosário Rodrigues
dc.creatorReis, Maysa Paula da Costa
dc.creatorDiniz, Danielle Guimarães Almeida
dc.creatorSá, Fabyola Amaral da Silva
dc.creatorAlves, Suzana Ferreira
dc.creatorCosta, Élson Alves
dc.creatorLino, Roberta Campos
dc.creatorPaula, José Realino de
dc.date.accessioned2018-09-05T11:46:18Z
dc.date.available2018-09-05T11:46:18Z
dc.date.issued2012
dc.description.abstractPreparations from Pimenta pseudocaryophyllus (Gomes) L.R. Landrum (Myrtaceae) have been widely used in Brazilian folk medicine. This study aims to evaluate the antimicrobial activity of the crude ethanol extracts, fractions, semipurified substances, and essential oils obtained from leaves of two chemotypes of P. pseudocaryophyllus and to perform the antinociceptive and anti- inflammatory screening. The ethanol extracts were purified by column chromatography and main compounds were spectrally characterised (1D and 2D 1 H and 13 C NMR). The essential oils constituents were identified by GC/MS. The broth microdilution method was used for testing the antimicrobial activity. The abdominal contortions induced by acetic acid and the ear oedema induced by croton oil were used for screening of antinociceptive and anti-inflammatory activities, respectively. The phytochemical analysis resulted in the isolation of pentacyclic triterpenes, flavonoids, and phenol acids. The oleanolic acid showed the best profile of antibacterial activity for Gram-positive bacteria (31.2–125 μg mL − 1 ), followed by the essential oil of the citral chemotype (62.5–250 μg mL − 1 ). Among the semipurified substances, Ppm5, which contained gallic acid, was the most active for Candida spp. (31.2 μg mL − 1 ) and Cryptococcus spp. (3.9–15.6 μg mL − 1 ). The crude ethanol extract and fractions from citral chemotype showed antinociceptive and anti-inflammatory effects.pt_BR
dc.identifier.citationPAULA, Joelma Abadia Marciano de. Phytochemical analysis and antimicrobial, antinociceptive, and anti-inflammatory activities of two chemotypes of pimenta pseudocaryophyllus (Myrtaceae). Evidence-Based Complementary and Alternative Medicine, London, v. 2012, p. 1-15, 2012.pt_BR
dc.identifier.doi10.1155/2012/420715
dc.identifier.issn1741-427X
dc.identifier.issne- 1741-4288
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15838
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePhytochemical analysis and antimicrobial, antinociceptive, and anti-inflammatory activities of two chemotypes of pimenta pseudocaryophyllus (Myrtaceae)pt_BR
dc.typeArtigopt_BR

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