Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma

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dc.creatorWatanabe, Satiro
dc.creatorWatanabe, Rogério Haruo
dc.creatorLeite, Angélica Ferreira Oton
dc.creatorAlencar, Rita de Cássia Gonçalves de
dc.creatorOliveira, José Carlos de
dc.creatorLeles, Cláudio Rodrigues
dc.creatorBatista, Aline Carvalho
dc.creatorMendonca, Elismauro Francisco de
dc.date.accessioned2018-10-29T11:17:33Z
dc.date.available2018-10-29T11:17:33Z
dc.date.issued2010
dc.description.abstractCell proliferation markers play an important role in the biological behavior of neoplasms. This study investigated the immunohistochemical expression of PCNA, Ki-67 and Cyclin B1 proteins based on the pattern of cell invasion in oral squamous cell carcinoma (OSCC). A total of 39 OSCC specimens and 13 samples of normal oral mucosa (control) were immunohistochemically analyzed. Protein expression was evaluated according to World Health Organization – Histological Malignancy Grading (WHO-HMG) and a specific grading system for invasion, graded from 1 to 4, varying from a consistently well-defined “pushing” border to diffuse infiltration and cellular dissociation, and was then correlated with clinical features. We found higher expression of Ki-67 and Cyclin B1 in OSCC when compared with the control group. High Ki-67 expression levels were more commonly seen in the floor of the mouth than in the tongue (P = 0.009). Cyclin B1 showed a positive correlation with histological grade, according to WHO-HMG criteria (P = 0.01). Our results suggest that Cyclin B1 is a reliable proliferation marker for indicating degree of tumor proliferation. Correlations between PCNA, Ki-67, Cyclin B1 and invasive tumor front with overall survival were not observed. Further studies are needed in order to elucidate whether cell proliferation activity at the tumor invasion front is related to prognosis. (J Oral Sci 52, 417-424, 2010)pt_BR
dc.identifier.citationWATANABE, Satiro et al. Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma. Journal of Oral Science, Tokyo, v. 52, n. 3, p. 417-424, 2010.pt_BR
dc.identifier.doi10.2334/josnusd.52.417
dc.identifier.issn1343-4934
dc.identifier.issne- 1880-4926
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16278
dc.language.isoengpt_BR
dc.publisher.countryOutrospt_BR
dc.publisher.departmentFaculdade de Odontologia - FO (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPCNApt_BR
dc.subjectCyclin B1pt_BR
dc.subjectPattern of invasionpt_BR
dc.subjectKi-67pt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.titleAnalysis of cell proliferation and pattern of invasion in oral squamous cell carcinomapt_BR
dc.typeArtigopt_BR

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