Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen a fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice

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dc.creatorPimenta, Fabiana Cristina
dc.creatorMiyaji, Eliane Namie
dc.creatorDau, Ana Paula de Mattos ArĂȘas
dc.creatorOliveira, Maria Leonor Sarno de
dc.creatorAndrade, Ana LĂșcia Sampaio Sgambatti de
dc.creatorHo, Paulo Lee
dc.creatorHollingshead, S. K.
dc.creatorLeite, Luciana Cezar de Cerqueira
dc.date.accessioned2018-06-27T12:54:07Z
dc.date.available2018-06-27T12:54:07Z
dc.date.issued2006-08
dc.description.abstractOne of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with elevated sequence identity in other viridans group streptococci. In this work, we demonstrate that intranasal immunization with a cholera toxin B subunit-PsaA fusion protein is able to protect mice against colonization with S. pneumoniae but does not significantly alter the natural oral or nasopharyngeal microbiota of mice.pt_BR
dc.identifier.citationPIMENTA, F. C. et. al. Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen a fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice. Infection and Immunity, Washington, v. 74, n. 8, p. 4939-4944, 2006.pt_BR
dc.identifier.doi10.1128/IAI.00134-06
dc.identifier.issn0019-9567
dc.identifier.issne-1098-5522
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15312
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e SaĂșde PĂșblica - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleIntranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen a fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of micept_BR
dc.typeArtigopt_BR

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