Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil

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dc.creatorHungria, Emerith Mayra
dc.creatorOliveira, Regiane Morillas de
dc.creatorSouza, Ana Lúcia Osório Maroclo de
dc.creatorCosta, Maurício Barcelos
dc.creatorSouza, Vânia Nieto Brito de
dc.creatorSilva, Eliane Aparecida
dc.creatorMoreno, Fátima Regina Vilani
dc.creatorNogueira, Maria Esther Salles
dc.creatorCosta, Maria Renata Sales Nogueira
dc.creatorSilva, Sônia Maria Usó Ruiz
dc.creatorBührer-Sékula, Samira
dc.creatorReed, Steven G.
dc.creatorDuthie, Malcolm S.
dc.creatorStefani, Mariane Martins de Araújo
dc.date.accessioned2019-01-29T10:31:22Z
dc.date.available2019-01-29T10:31:22Z
dc.date.issued2012
dc.description.abstractNew Mycobacterium leprae protein antigens can contribute to improved serologic tests for leprosy diagno-sis/classification and multidrug therapy (MDT) monitoring. This study describes seroreactivity to M. leprae pro-teins among participants from three highly endemic leprosy areas in Brazil: central-western Goiânia/Goiás (GO) (n = 225), Rondonópolis/Mato Grosso (MT) (n = 764) and northern Prata Village/Pará (PA) (n = 93). ELISA was performed to detect IgG to proteins (92f, 46f, leprosy IDRI diagnostic-1, ML0405, ML1213) and IgM to phenolic gly-colipid-I (PGL-I). Multibacillary (MB) leprosy had positive rates for PGL-I that were similar to those for proteins; however, some anti-PGL-I-negative subjects were positive for proteins, suggesting that adding protein antigen to PGL-I can enhance the sensitivity of MB leprosy detection. In MT, different degrees of seroreactivity were observed and ranked for MB, former patients after MDT, paucibacillary (PB) leprosy, household contact (HHC) and endemic control (EC) groups. The seroreactivity of PB patients was low in GO and MT. HHCs from different endemic sites had similar IgG antibody responses to proteins. 46f and 92f were not recognised by most tuberculosis patients, ECs or HHCs within GO, an area with high BCG vaccination coverage. Low positivity in EC and HHC was observed in PA and MT. Our results provide evidence for the development of an improved serologic test that could be widely applicable for MB leprosy testing in Brazil.pt_BR
dc.identifier.citationHUNGRIA, Emerith Mayra et al. Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, p. 104-111, 2012.pt_BR
dc.identifier.doi10.1590/S0074-02762012000900017
dc.identifier.issn0074-0276
dc.identifier.issn1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16894
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSerologypt_BR
dc.subjectLeprosypt_BR
dc.subjectDiagnosispt_BR
dc.titleSeroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazilpt_BR
dc.typeArtigopt_BR

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