Cerebral and cardiac amyloidosis in autopsied elderly individuals

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dc.creatorNunes, Lucas Martins de Exel
dc.creatorSalge, Ana Karina Marques
dc.creatorOliveira, Flávia Aparecida de
dc.creatorTeixeira, Vicente de Paula Antunes
dc.creatorReis, Marlene Antônia dos
dc.date.accessioned2018-08-30T10:57:37Z
dc.date.available2018-08-30T10:57:37Z
dc.date.issued2006
dc.description.abstractINTRODUCTION: Amyloidosis in elderly individuals can be an independent alteration and a characteristic of aging. However, the clinical, pathophysiologic, and biochemical characteristics of amyloidosis related to age remain uncertain. OBJECTIVE: The purpose of this study was to determine the extent to which the heart and/or the brain of individuals aged 60 years or over exhibits amyloid deposits. MATERIALS AND METHODS: The autopsy findings of individuals who were at least 60 years old were studied. The autopsies took place between the years of 1976 and 2000. A total of 10 cases were selected that had hearts without cardiopathies, had negative serology for Chagas’ disease, and had brains without morphological changes related to encephalopathies. Slides with fragments of heart and brain were processed and analyzed using polarized and common light microscopy. RESULTS: Of the 10 cases, 4 were positive for amyloidosis. All had positive findings in the brain, and 1 case also had positive findings in the heart. Among the positive cases, 50% were of people aged 60 to 69 years. There appeared to be a relationship between the presence of amyloid deposits and the ratio of brain and body weight, with the ratio in the positive cases being smaller than in the negative cases. CONCLUSIONS: The analysis of amyloid deposits in the brains and hearts of elderly individuals shows that such deposits may lead to a systemic attack of senility, common to natural aging. It is not certain that beta-amyloid deposits would alone bring such drastic repercussions to the individual. Some additional disorders of the organism could cause the breakdown of the natural balance related to the accumulation of these proteins, leading the way to the pathological contexts of amyloidosis.pt_BR
dc.description.resumoINTRODUÇÃO: A amiloidose em idosos pode ser uma alteração independente e própria do envelhecimento. Entretanto, as características clínicas, fisiopatológicas e bioquímicas da Amiloidose relacionada à idade ainda permanecem incertas. OBJETIVO: Verificar se o coração e o encéfalo de indivíduos acima de 60 anos apresentavam depósito amilóide. MATERIAL E MÉTODOS: Foram estudados laudos consecutivos de autópsias de indivíduos acima de 60 anos realizadas entre 1976 e 2000, que apresentavam corações sem cardiopatias, com sorologia negativa para Doença de Chagas e encéfalos sem alterações morfológicas de encefalopatias, chegando a um n de 10 casos. Lâminas de fragmentos do coração e de encéfalo foram processadas e analisadas em microscopia de luz comum e polarizada. RESULTADOS: Dos 10 casos, 3 apresentaram depósito amilóide no encéfalo e 1 no encéfalo e no coração. Em 50% dos casos, os indivíduos tinham entre 60 e 69 anos. A relação entre o peso encefálico e o peso corporal mostrou 117 CLINICS 2006;61(2):113-8 Cerebral and cardiac amyloidosis in autopsied elderly individuals Nunes LME et al. REFERENCES 1. IBGE – Instituto Brasileiro de Geografia e Estatística, 2003. (Acessado 2005 Abril.22);Disponível: www.ibge.gov.br/home/populacao/ tabuadavida/evolucao_da_mortalidade.shtm 2. Lie JT, Hammond PI. Pathology of the senescent heart: anatomic observations on 237 autopsy studies of patients 90 to 105 years old. Mayo Clin Proc. 1988;63:552-64. 3. WHO-IUIS Nomenclature Sub-Committee. Nomenclature of amyloid and amyloidosis. Bulletin of the Word Health Organization. 1993;71:105-8. 4. Cotran RS, Kumar V, Stanley LR, Shoen FJ. Doenças da Imunidade In: Cotran RS, Kumar V, Stanley LR, Shoen FJ, editors. Robbins Patologia Estrutural e Funcional. 6ªed. Rio de Janeiro: Guanabara Koogan; 2000. p. 168-229. 5. Kyle RA, Spittell PC, Gertz MA, Li CY, Edwards WD, Olson LJ, et al. Am J Med. 1996;101:395-400. 6. Kitzman DW, Edwards WD. Age-related changes in the anatomy of the normal human heart. J Gerontol. 1990;45:33-9. 7. Nitrini, R. Epidemiologia da doença de Alzheimer no Brasil. Revista de Psiquiatria clínica –edição internet-1999;26(5). Departamento e Instituto de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo. (Acessado 2003 Jun.06); Disponível em: www.hcnet.usp.br/ ipq/revista/r265/index.html 8. Gandy S. The role of cerebral amyloid β accumulation in common forms of Alzheimer disease. J Clin Invest. 2005;115:1121–29. 9. Weller RO, Yow HY, Preston SD, Mazanti I, Nicoll JA. Cerebrovascular disease is a major factor in the failure of elimination of Abeta from aging human brain: implications for therapy of Alzheimer’s disease. Ann NY Acad Sci. 2002;997:162-8. 10. Hopper MW, Vogel FS. The limbic system in Alzheimer’s disease. A neuropathologic investigation. Am J Pathol. 1976;85:1-20. 11. Walker LC, Masters C, Beyreuther K, Price DL. Amyloid in the brains of aged squirrel monkeys. Acta Neuropathol. 1990;80:381-7. 12. Agius Lm. Beta-amyloidosis as an index of activity of the Alzheimer process rather than as primary mechanism of neuronal injury in organic dementia. Med Hypotheses. 2003;60:880-5. 13. Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH. Alzheimer’s disease. A double-labeling immunohistochemical study of senile plaques. Am J Pathol. 1988;132:86-101. 14. Cornwell GG, Murdoch WL, Kyle RA, Westmark P, Pitkänen P. Frequency and distribution of senile cardiovascular amyloid. Am J of Med. 1983;75:618-23. 15. Saltzman E, Mason JB. Enteral nutrition in the elderly In: Rombeau JL, Rolandelli RH, editors. Clinical nutrition. Enteral and tube feeding. 3th ed. Philadelphia: W B Saunders Company; 1997. p. 385-402. ter uma associação significativa com os casos positivos, sendo esta menor em relação aos negativos. CONCLUSÃO: A análise conjunta de depósitos amilóides em encéfalo e coração de indivíduos idosos talvez direcione para um acometimento sistêmico comum ao envelhecimento natural. Alguma alteração adicional do organismo poderia determinar a quebra de um equilíbrio natural sobre o acúmulo dessas proteínas, levando dessa forma aos contextos patológicos da amiloidose.pt_BR
dc.identifier.citationNUNES, Lucas Martins de Excel et al. Cerebral and cardiac amyloidosis in autopsied elderly individuals. Clinics, São Paulo, v. 61, n. 2, p. 113-118, 2006.pt_BR
dc.identifier.doi10.1590/S1807-59322006000200005
dc.identifier.issne- 1980-5322
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15781
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Enfermagem - FEN (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAutopsypt_BR
dc.subjectAmyloidosispt_BR
dc.subjectElderlypt_BR
dc.subjectEncephalonpt_BR
dc.subjectHeartpt_BR
dc.subjectAutópsiapt_BR
dc.subjectAmiloidosept_BR
dc.subjectCoraçãopt_BR
dc.subjectEncéfalopt_BR
dc.subjectEnvelhecimentopt_BR
dc.titleCerebral and cardiac amyloidosis in autopsied elderly individualspt_BR
dc.title.alternativeBeta-fibrilose encefálica e cardíaca em idosos autopsiadospt_BR
dc.typeArtigopt_BR

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