Hepatitis C prevalence and risk factors in hemodialysis patients in central Brazil: a survey by polymerase chain reaction and serological methods

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dc.creatorCarneiro, Megmar Aparecida dos Santos
dc.creatorMartins, Regina Maria Bringel
dc.creatorTeles, Sheila Araujo
dc.creatorSilva, Simonne Almeida e
dc.creatorLopes, Carmem Luci Rodrigues
dc.creatorCardoso, Divina das Dôres de Paula
dc.creatorVanderborght, Bart O. M.
dc.creatorYoshida, Clara Fumiko Tachibana
dc.date.accessioned2019-01-15T14:50:51Z
dc.date.available2019-01-15T14:50:51Z
dc.date.issued2001-08
dc.description.abstractAn hemodialysis population in Central Brazil was screened by polymerase chain reaction (PCR) and serological methods to assess the prevalence of hepatitis C virus (HCV) infection and to investigate associated risk factors. All hemodialysis patients (n=428) were interviewed in eight dialysis units in Goiânia city. Blood samples were collected and serum samples screened for anti-HCV antibodies by an enzyme-linked immunosorbent assay (ELISA). Positive samples were retested for confirmation with a line immunoassay (LIA). All samples were also tested for HCV RNA by the PCR. An overall prevalence of 46.7% (CI 95%: 42-51.5) was found, ranging from 20.7% (CI 95%: 8.8-38.1) to 90.4% (CI 95%: 79.9-96.4) depending on the dialysis unit. Of the 428 patients, 185 were found to be seropositive by ELISA, and 167 were confirmed positive by LIA, resulting in an anti-HCV prevalence of 39%. A total of 131 patients were HCV RNA-positive. HCV viremia was present in 63.5% of the anti-HCV-positive patients and in 10.3% of the anti-HCV-negative patients. Univariate analysis of risk factors showed that the number of previous blood transfusions, transfusion of blood before mandatory screening for anti-HCV, length of time on hemodialysis, and treatment in multiple units were associated with HCV positiv-ity. However, multivariate analysis revealed that blood transfusion before screening for anti-HCV and length of time on hemodialysis were significantly associated with HCV infection in this population. These data suggest that nosocomial transmission may play a role in the spread of HCV in the dialysis units studied. In addition to anti-HCV screening, HCV RNA detection is necessary for the diagnosis of HCV infection in hemodialysis patients.pt_BR
dc.identifier.citationCARNEIRO, Megmar A. S.; MARTINS, Regina M. B.; TELES, Sheila A.; SILVA, Simonne A.; LOPES, Carmen L.; CARDOSO, Divina D. P.; VANDERBORGHT, Bart O. M.; YOSHIDA, Clara F. T. Hepatitis C prevalence and risk factors in hemodialysis patients in central Brazil: a survey by polymerase chain reaction and serological methods. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 765-769, 2001.pt_BR
dc.identifier.doi10.1590/S0074-02762001000600003
dc.identifier.issn0074-0276
dc.identifier.issne- 1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16734
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCentral Brazilpt_BR
dc.subjectHepatitis Cpt_BR
dc.subjectHemodialysispt_BR
dc.subjectPrevalencept_BR
dc.subjectRisk factorspt_BR
dc.titleHepatitis C prevalence and risk factors in hemodialysis patients in central Brazil: a survey by polymerase chain reaction and serological methodspt_BR
dc.typeArtigopt_BR

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