Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice

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dc.creatorFlorentino, Iziara Ferreira
dc.creatorNascimento, Marcus Vinicius Mariano
dc.creatorCarvalho, Pablinny Moreira Galdino de
dc.creatorBrito, Adriane Ferreira de
dc.creatorRocha, Fabio Fagundes da
dc.creatorTonussi, Carlos Rogerio
dc.creatorLima, Thereza Christina Monteiro de
dc.creatorPaula, José Realino de
dc.creatorCosta, Elson Alves
dc.date.accessioned2018-09-06T10:57:19Z
dc.date.available2018-09-06T10:57:19Z
dc.date.issued2013-09
dc.description.abstractThe Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba’s underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.pt_BR
dc.identifier.citationFLORENTINO, Iziara F. et al. Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 85, n. 3, p. 987-997, Sept. 2013.pt_BR
dc.identifier.doi10.1590/S0001-37652013000300011
dc.identifier.issn0001-3765
dc.identifier.issn1678-2690
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15862
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAcariçobapt_BR
dc.subjectHydrocotyle umbellata L.pt_BR
dc.subjectAnti-inflammatorypt_BR
dc.subjectBiomedical sciencespt_BR
dc.subjectAntinociceptivept_BR
dc.titleEvaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in micept_BR
dc.typeArtigopt_BR

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