Excitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus

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dc.creatorCustódio, Carlos Henrique Xavier
dc.creatorIanzer, Danielle Alves
dc.creatorLima, Augusto Martins
dc.creatorMarins, Fernanda Ribeiro
dc.creatorPedrino, Gustavo Rodrigues
dc.creatorVaz, Gisele Cristiane
dc.creatorMenezes, Gustavo Batista de
dc.creatorNalivaiko, Eugene
dc.creatorFontes, Marco Antônio Peliky
dc.date.accessioned2018-08-22T13:13:59Z
dc.date.available2018-08-22T13:13:59Z
dc.date.issued2014-11
dc.description.abstractThe dorsomedial hypothalamus (DMH) and lateral/dorsolateral periaqueductal gray (PAG) are anatomically and functionally connected. Both the DMH and PAG depend on glutamatergic inputs for activation. We recently reported that removal of GABA-ergic tone in the unilateral DMH produces: asymmetry, that is, a right- (R-) sided predominance in cardiac chronotropism, and lateralization, that is, a greater increase in ipsilateral renal sympathetic activity (RSNA). In the current study, we investigated whether excitatory amino acid (EAA) receptors in the DMH–PAG pathway contribute to the functional interhemispheric difference. In urethane (1.2 to 1.4 g/kg, i.p.) anesthetized rats, we observed that: (i) nanoinjections of N-methyl D-aspartate (NMDA 100 pmol/100 nl) into the unilateral DMH produced the same right-sided predominance in the control of cardiac chronotropy, (ii) nanoinjections of NMDA into the ipsilateral DMH or PAG evoked lateralized RSNA responses, and (iii) blockade of EAA receptors in the unilateral DMH attenuated the cardiovascular responses evoked by injection of NMDA into either the R- or left- (L-) PAG. In awake rats, nanoinjection of kynurenic acid (1 nmol/100 nL) into the L-DMH or R- or L-PAG attenuated the tachycardia evoked by air stress. However, the magnitude of stress-evoked tachycardia was smallest when the EAA receptors of the R-DMH were blocked. We conclude that EAA receptors contribute to the right-sided predominance in cardiac chronotropism. This interhemispheric difference that involves EAA receptors was observed in the DMH but not in the PAG.pt_BR
dc.identifier.citationXAVIER, Carlos Henrique; IANZER, Danielle; LIMA, Augusto Martins; MARINS, Fernanda Ribeiro; PEDRINO, Gustavo Rodrigues; VAZ, Gisele; MENEZES, Gustavo Batista; NALIVAIKO, Eugene; FONTES, Marco Antônio Peliky. Excitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamus. PLoS One, San Francisco, v. 9, e112412, Nov. 2014.pt_BR
dc.identifier.doi10.1371/journal.pone.0112412
dc.identifier.issne- 1932-6203
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15693
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleExcitatory amino acid receptors mediate asymmetry and lateralization in the descending cardiovascular pathways from the dorsomedial hypothalamuspt_BR
dc.typeArtigopt_BR

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