Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteers

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dc.creatorCarneiro, Danilo Maciel
dc.creatorFreire, Ramias Calixto
dc.creatorHonório, Tereza Cristina de Deus
dc.creatorZoghaib, Iury Valentim Jorge
dc.creatorCardoso, Fabiana Fernandes de Santana e Silva
dc.creatorTresvenzol, Leonice Manrique Faustino
dc.creatorPaula, José Realino de
dc.creatorSousa, Ana Luiza Lima
dc.creatorJardim, Paulo César Brandão Veiga
dc.creatorCunha, Luiz Carlos da
dc.date.accessioned2018-09-26T12:17:14Z
dc.date.available2018-09-26T12:17:14Z
dc.date.issued2014
dc.description.abstractIn this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (𝑛 = 12) that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900mg/day), placebo (corn starch, 900mg/day), or hydrochlorothiazide (25mg/day), separated by a 10-day washout period. Each volunteer served as his own control, and the groups’ results were compared. We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug.The diuretic effect of EADE was assessed by monitoring the volunteers’ water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported. The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.pt_BR
dc.identifier.citationCARNEIRO, Danilo Maciel et al. Randomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteers. Evidence-Based Complementary and Alternative Medicine, London, v. 2014, e760683, 2014.pt_BR
dc.identifier.doi10.1155/2014/760683
dc.identifier.issne- 1741-4288
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16052
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentFaculdade de Enfermagem - FEN (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleRandomized, double-blind clinical trial to assess the acute diuretic effect of Equisetum arvense (Field horsetail) in healthy volunteerspt_BR
dc.typeArtigopt_BR

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