Preferential transcription of Paracoccidioides brasiliensis genes: host niche and time-dependent expression

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dc.creatorPereira, Maristela
dc.creatorBailão, Alexandre Melo
dc.creatorParente, Juliana Alves
dc.creatorBorges, Clayton Luiz
dc.creatorFurlaneto, Silvia Maria Salem Izacc
dc.creatorSoares, Célia Maria de Almeida
dc.date.accessioned2018-05-28T12:08:37Z
dc.date.available2018-05-28T12:08:37Z
dc.date.issued2009-05
dc.description.abstractParacoccidioides brasiliensis causes infection through inhalation by the host of airborne propagules from the mycelium phase of the fungus. This fungus reaches the lungs, differentiates into the yeast form and is then disseminated to virtually all parts of the body. Here we review the identification of differentially-expressed genes in host-interaction conditions. These genes were identified by analyzing expressed sequence tags (ESTs) from P. brasiliensis cDNA libraries. The P. brasiliensis was recovered from infected mouse liver as well as from fungal yeast cells incubated in human blood and plasma, mimicking fungal dissemination to organs and tissues and sites of infection with inflammation, respectively. In addition, ESTs from a cDNA library of P. brasiliensis mycelium undergoing the transition to yeast were previously analyzed. Together, these studies reveal significant changes in the expression of a number of genes of potential importance in the host-fungus interaction. In addition, the unique and divergent representation of transcripts when the cDNA libraries are compared suggests differential gene expression in response to specific niches in the host. This analysis of gene expression patterns provides details about host-pathogen interactions and peculiarities of sites within the host.pt_BR
dc.identifier.citationPEREIRA, Maristela et.al. Preferential transcription of Paracoccidioides brasiliensis genes: host niche and time-dependent expression. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 3, p. 486-491, May 2009.pt_BR
dc.identifier.issn0074-0276
dc.identifier.issne-1678-8060
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15092
dc.language.isoengpt_BR
dc.publisher.countrySuicapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectParacoccidioides brasiliensispt_BR
dc.subjectHost-nichespt_BR
dc.subjectInfected tissuespt_BR
dc.titlePreferential transcription of Paracoccidioides brasiliensis genes: host niche and time-dependent expressionpt_BR
dc.typeArtigopt_BR

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