Immunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infection

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dc.creatorSousa, Eduardo Martins de
dc.creatorCosta, Adeliane Castro da
dc.creatorTrentini, Monalisa Martins
dc.creatorAraújo Filho, João Alves de
dc.creatorKipnis, André
dc.creatorJunqueira-Kipnis, Ana Paula
dc.date.accessioned2018-12-12T11:50:21Z
dc.date.available2018-12-12T11:50:21Z
dc.date.issued2012-10-25
dc.description.abstractTuberculosis (TB) remains a major global health problem. The only vaccine against tuberculosis, attenuated Mycobacterium bovis Bacillus Calmette-Guerin (BCG), has demonstrated relatively low efficacy and does not provide satisfactory protection against the disease in adults. More effective vaccines and better therapies are urgently needed to reduce the global spread of TB. This study evaluated the immunogenicity of a recombinant M. tuberculosis Ag85C-MPT51-HspX fusion protein (CMX) in mice and individuals with active tuberculosis. BALB/c mice were immunized with the CMX protein liposome-encapsulated with CpG DNA or with CpGDNA liposome-encapsulated, liposome or saline as negative controls. The immunization produced high levels of anti-CMX -specific IgG1 and IgG2a antibodies and induced an increase in the relative and absolute numbers of specific TCD4 IFN-c+ and TNF-a+ cells in the spleen. Sera from a cohort of individuals with active tuberculosis contained higher levels of IgG and IgM that recognized CMX when compared to healthy individuals. In conclusion, this protein was shown to be immunogenic both in mice and humans.pt_BR
dc.identifier.citationSOUSA, Eduardo Martins de; COSTA, Adeliane Castro da; TRENTINI, Monalisa Martins; ARAÚJO FILHO, João Alves de; KIPNIS, André; JUNQUEIRA-KIPINIS, Ana Paula. Immunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infection. Plos One, San Francisco, v. 7, n.10, p. e47781, 2012.pt_BR
dc.identifier.doi10.1371/journal.pone.0047781
dc.identifier.issne- 1932-6203
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16567
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleImmunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infectionpt_BR
dc.typeArtigopt_BR

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