Vasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora ) extract in rats

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dc.creatorBufáiçal, Daniela Medeiros Lobo de Andrade
dc.creatorReis, Carolina de Fatima
dc.creatorCastro, Patrícia Ferreira da Silva
dc.creatorBorges, Leonardo Luiz
dc.creatorAmaral, Nathalia Oda
dc.creatorTorres, Ieda Maria Sapateiro
dc.creatorRezende, Stefani Garcia
dc.creatorGil, Eric de Souza
dc.creatorConceição, Edemilson Cardoso da
dc.creatorPedrinho, Gustavo Rodrigues
dc.creatorRocha, Matheus Lavorenti
dc.date.accessioned2018-09-12T11:05:10Z
dc.date.available2018-09-12T11:05:10Z
dc.date.issued2015
dc.description.abstractThis study’s aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and β- adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness.pt_BR
dc.identifier.citationANDRADE, Daniela Medeiros Lobo de et al. Vasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora ) extract in rats. Evidence-Based Complementary and Alternative Medicine, London, v. 2015, p. 1-8, 2015.pt_BR
dc.identifier.doi10.1155/2015/696135
dc.identifier.issn1741-427X
dc.identifier.issne- 1741-4288
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15902
dc.language.isoengpt_BR
dc.publisher.countryGra-bretanhapt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleVasorelaxant and hypotensive effects of jaboticaba fruit ( Myrciaria cauliflora ) extract in ratspt_BR
dc.typeArtigopt_BR

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