Failure of nitric oxide production by macrophages and decrease in CD4+ T cells in oral paracoccidioidomycosis: possible mechanisms that permit local fungal multiplication

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dc.creatorBatista, Aline Carvalho
dc.creatorSoares, Cléverson Teixeira
dc.creatorLara, Vanessa Soares
dc.date.accessioned2018-10-26T11:39:33Z
dc.date.available2018-10-26T11:39:33Z
dc.date.issued2005-10
dc.description.abstractParacoccidioidomycosis is a chronic granulomatous disease that induces a specific inflammatory and immune response. The participation of nitric oxide (NO), a product of the inducible nitric oxide synthase enzyme (iNOS), as an important fungicidal molecule against Paracoccidioides brasiliensis has been demonstrated. In order to further characterize the Oral Paracoccidioidomycosis (OP), we undertook an immunohistochemical study of iNOS + , CD45RO + , CD3 + , CD8 + , CD20 + , CD68 + cells and mast cells. The samples were distributed in groups according to the number of viable fungi per mm 2 . Our results showed weak immunolabeling for iNOS in the multinucleated giant cells (MNGC) and in most of the mononuclear (MN) cells, and the proportion of iNOS + MN/MNGC cells in the OP were comparable to Control (clinically healthy oral tissues). Additionally, our analysis revealed a similarity in the number of CD4 + cells between the Control and the OP groups with higher numbers of fungi. These findings suggest that a low expression of iNOS and a decrease in the CD4 + T cells in OP may represent possible mechanisms that permit the local fungal multiplication and maintenance of active oral lesions.pt_BR
dc.identifier.citationBATISTA, Aline Carvalho; SOARES, Cleverson Teixeira; LARA, Vanessa SoareS. Failure of nitric oxide production by macrophages and decrease in CD4+ T cells in oral paracoccidioidomycosis: possible mechanisms that permit local fungal multiplication. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 47, n. 5, p. 267-273, Sept./Oct. 2005.pt_BR
dc.identifier.doi10.1590/S0036-46652005000500006
dc.identifier.issne- 1678-9946
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16253
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Odontologia - FO (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectParacoccidioidomycosispt_BR
dc.subjectImmune cellspt_BR
dc.subjectNitric oxidept_BR
dc.titleFailure of nitric oxide production by macrophages and decrease in CD4+ T cells in oral paracoccidioidomycosis: possible mechanisms that permit local fungal multiplicationpt_BR
dc.typeArtigopt_BR

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