Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice

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dc.creatorSilva, Carolina Ribeiro e
dc.creatorVieira, Pabline Marinho
dc.creatorLee, Chen Chen
dc.date.accessioned2018-10-17T10:31:22Z
dc.date.available2018-10-17T10:31:22Z
dc.date.issued2013
dc.description.abstractDuguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as “sofre-do-rim-quem-quer” and “araticum-seco”, is a shrub of the Annonaceae family that grows in several regions of Brazil. Infusions of its leaves and twigs are used in folk medicine to treat rheumatism and renal colic, whereas the seed powder is mixed with water to treat pediculosis. Studies on the plant have reported biological activities with cytotoxic, antitumoral, trypanocidal, leishmanicidal, antiplasmodial, and antiprotozoal effects. Our previous studies using a prophage l induction test (SOS-Inductest) and the micronucleus assay demonstrated that D. furfuracea lyophilized leaf extract (DFE) displayed cytotoxic but not genotoxic activity. In the present study, antigenotoxic and anticytotoxic activities of DFE were evaluated using SOS-Inductest and mouse bone marrow micronucleus tests. Our results showed that DFE decreased the induction of either prophage l (P < 0.05; SOS-Inductest) or micronucleated polychromatic erythrocytes (P < 0.05; micronucleus test) at all doses, suggesting antigenotoxic activity in both tests. On assessing the anticytotoxic activity of DFE, a significant increase in the number of bacteria at lower doses (P < 0.05) as well as a significant increase in the polychromatic and normochromatic erythrocyte ratio were observed (P <0.05), demonstrating the anticytotoxic activity of DFE. Thus, D. furfuracea displayed antigenotoxic and anticytotoxic activity in both assays.pt_BR
dc.identifier.citationSILVA, C. R.; VIEIRA, P. M.; L., Chen-Chen. Antigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and mice. Genetics and Molecular Research, Ribeirão Preto, v. 12, n. 3, p. 3718-3725, 2013.pt_BR
dc.identifier.doi10.4238/2013.September.19.2
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16189
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDuguetia furfuraceapt_BR
dc.subjectSOS-inductestpt_BR
dc.subjectAntigenotoxicitypt_BR
dc.subjectMicronucleus testpt_BR
dc.subjectAnticytotoxicitypt_BR
dc.titleAntigenotoxic and anticytotoxic activity of Duguetia furfuracea in bacteria and micept_BR
dc.typeArtigopt_BR

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