Preparation of pellets containing Pothomorphe umbellata extracts by extrusion-spheronization: improvement of 4-nerolidylcatechol photostability

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dc.creatorAraújo Júnior, César Aparício de
dc.creatorCosta, Fernanda S. de Oliveira
dc.creatorTaveira, Stephânia Fleury
dc.creatorMarreto, Ricardo Neves
dc.creatorValadares, Marize Campos
dc.creatorLima, Eliana M.
dc.date.accessioned2019-09-09T11:57:03Z
dc.date.available2019-09-09T11:57:03Z
dc.date.issued2013-02
dc.description.abstractPothomorphe umbellata (L.) Miq., Piperaceae, has been extensively used in Brazilian folk medicine and it is well known for its strong antioxidant properties. However, its main active constituent, 4-nerolydilcatechol (4-NC), is sensitive to ultraviolet and visible light, which can limit the use of intermediate and final herbal preparations of this species. In the present work, coated multiparticulate solid dosage forms of P. umbellata were obtained with the purpose of increasing the stability of 4-NC. P. umbellata extract was used as a wetting liquid for the preparation of pellets by extrusion-spheronization. Pellets were coated in a fluidized bed by three different polymers (hydroxypropylmethylcellulose (HPMC), polyvynilpirrolidone K-30 (PVP-K30), and polyvinyl alcohol-polyethylene glycol graft-copolymer (PVA- PEG)). 4-NC photostability was evaluated by an accelerated photostability protocol. Pellets showed a narrow size distribution and low friability. 4-NC photodegradation followed a second order degradation kinetics with similar k values for the percolate, uncoated pellets and HPMC coated pellets. Photoprotection was higher in pellets coated with PVP-K30 and PVA-PEG. PVA-PEG coated pellets with 6 and 9% weight gain resulted in a final concentration of 4-NC approximately cinco times higher than uncoated pellets or liquid extracts, suggesting the potential of this formulation as a multiparticulate solid dosage form for P. umbellata extracts.pt_BR
dc.identifier.citationAraújo-Júnior, César Aparício de et al. Preparation of pellets containing Photomorphe umbellata extracts by extrusion-spheronization: improvement of 4-nerolidylcathecol photostability. Revista Brasileira de Farmacognosia, Curtiba, v. 23, n. 1, p. 169-174, Jan./Feb. 2013.pt_BR
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/18103
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFaculdade de Farmácia - FF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectExtrusion-spheronizationpt_BR
dc.subjectFilm coatingpt_BR
dc.subjectHerbal extractspt_BR
dc.subjectMultiparticulate solid dosage formspt_BR
dc.subjectNerolidylcatecholpt_BR
dc.subjectPhotostabilitypt_BR
dc.titlePreparation of pellets containing Pothomorphe umbellata extracts by extrusion-spheronization: improvement of 4-nerolidylcatechol photostabilitypt_BR
dc.typeArtigopt_BR

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