Down-regulation of CTLA-4 by HIV-1 nef protein

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dc.creatorEl Far, Mohamed
dc.creatorIsabelle, Catherine
dc.creatorChomont, Nicolas
dc.creatorBourbonnière, Martin
dc.creatorFonseca, Simone Gonçalves da
dc.creatorAncuta, Petronela
dc.creatorPeretz, Yoav
dc.creatorChouikh, Younes
dc.creatorHalwani, Rabih
dc.creatorSchwartz, Olivier
dc.creatorMadrenas, Joaquı́n
dc.creatorFreeman, Gordon J.
dc.creatorRouty, Jean-Pierre
dc.creatorHaddad, Elias K.
dc.creatorSékaly, Rafick-Pierre
dc.date.accessioned2018-08-17T11:52:48Z
dc.date.available2018-08-17T11:52:48Z
dc.date.issued2013-01
dc.description.abstractHIV-1 Nef protein down-regulates several cell surface receptors through its interference with the cell sorting and trafficking machinery. Here we demonstrate for the first time the ability of Nef to down-regulate cell surface expression of the negative immune modulator CTLA-4. Down-regulation of CTLA-4 required the Nef motifs DD175, EE155 and LL165, all known to be involved in vesicle trafficking. Disruption of the lysosomal functions by pH-neutralizing agents prevented CTLA-4 down- regulation by Nef, demonstrating the implication of the endosomal/lysosomal compartments in this process. Confocal microscopy experiments visualized the co-localization between Nef and CTLA-4 in the early and recycling endosomes but not at the cell surface. Overall, our results provide a novel mechanism by which HIV-1 Nef interferes with the surface expression of the negative regulator of T cell activation CTLA-4. Down-regulation of CTLA-4 may contribute to the mechanisms by which HIV-1 sustains T cell activation, a critical step in viral replication and dissemination.pt_BR
dc.identifier.citationEL-FAR, Mohamed; ISABELLE, Catherine; CHOMONT, Nicolas; BOURBONNIÈRE, Martin; FONSECA, Simone; ANCUTA, Petronela; PERETZ, Yoav; CHOUIKH,Younes; HALWANI, Rabih; SCHWARTZ, Olivier; MADRENAS, Joaquín; FREEMAN, Gordon J.; ROUTY, Jean-Pierre; HADDAD, Elias K.; SÉKALY, Rafick-Pierre. Down-regulation of CTLA-4 by HIV-1 nef protein. Plos One, San Francisco, v. 8, n. 1, p. e54295, Jan. 2013.pt_BR
dc.identifier.doi10.1371/journal.pone.0054295
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15645
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleDown-regulation of CTLA-4 by HIV-1 nef proteinpt_BR
dc.typeArtigopt_BR

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