Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells

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dc.creatorCoelho, L. S.
dc.creatorFelício, Leandro Prado
dc.creatorMiranda, Cristiane Torres de
dc.creatorSilva, E. M. da
dc.creatorVale, Camila Regina do
dc.creatorLima, D.C.S.
dc.creatorDuarte, S. R.
dc.creatorFerreira, Heleno Dias
dc.creatorLee, Chen Chen
dc.creatorCarvalho, S.
dc.date.accessioned2018-10-17T10:44:23Z
dc.date.available2018-10-17T10:44:23Z
dc.date.issued2011
dc.description.abstractMutagenic and antimutagenic activities of the medicinal plant Duguetia furfuracea were assessed using SMART/ wing and ring-X-loss tests. For the ring-X-loss test, 2- to 3-day-old Drosophila melanogaster ring-X-lineage males and virgin ywsn 3 females received D. furfuracea infusion at doses of 0.085, 0.042, or 0.014 g/mL for 24 h. We found that D. furfuracea did not produce any mutagenic effects in D. melanogaster germinative cells. The somatic cells of D. melanogaster were analyzed using the SMART/ wing test involving three lineages - mwh, flr 3 , and ORR - and the same doses of D. furfuracea infusion employed in the ring-X-loss test, as well as 20 mM urethane. The results of both standard (ST) and high bioactivation (HB) crosses showed absence of mutagenic activity of D. furfuracea. In contrast, in both ST and HB crosses, we observed a modulatory effect of D. furfuracea against the genotoxic activity of urethane.pt_BR
dc.identifier.citationCOELHO, L. S. et al. Modulatory effects of Duguetia furfuracea (A. St Hil) Benth and Hook.f in Drosophila melanogaster somatic and germinative cells. Genetics and Molecular Research, Ribeirão Preto, v. 10, n. 1, p. 75-85, 2011.pt_BR
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16194
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntimutagenicitypt_BR
dc.subjectMutagenicitypt_BR
dc.subjectDuguetia furfuraceapt_BR
dc.subjectGenotoxicitypt_BR
dc.titleModulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cellspt_BR
dc.typeArtigopt_BR

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