Epidemiologia da infecção pelo vírus da hepatite C em catadores de materiais recicláveis em Goiânia, Goiás
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Data
2012-02-29
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Universidade Federal de Goiás
Resumo
Hepatitis C represents an important public health problem. Although acute hepatitis C
virus (HCV) infection is often asymptomatic, 50 to 85% of these cases progress to
chronic disease, and can lead to liver cirrhosis and hepatocellular carcinoma. Accidents
involving contaminated sharps occur in recyclable waste collectors as a result of contact
with glass, ferrous sharp, needles and syringes, demonstrating, thus, the increased risk
of these professionals in acquiring infections by the parenteral route, such as hepatitis C.
There is currently very little data on HCV infection among recyclable waste collectors.
This study aimed to investigate the epidemiological and molecular profile of the
hepatitis C virus infection among recyclable waste collectors in Goiânia, Goiás. A total
of 431individuals were interviewed for socio-demographic characteristics and risk
factors for HCV infection. Blood samples were collected and sera were tested for the
presence of antibodies to HCV (anti-HCV) using an enzyme-linked immunosorbent
assay (ELISA) and immunoblot. All samples were submitted to HCV RNA detection by
polymerase chain reaction (PCR) with primers complementary to the conserved area of
the 5’ non-coding (NC) region of HCV. Positive HCV RNA samples were genotyped
by direct sequencing analysis of the NS5B region of viral genome, followed by
phylogenetic analysis. The HCV infection prevalence was 1.6% (95% CI: 0.6-3.6) in
recyclable waste collectors in Goiânia-GO. In a multivariate analysis, history of
sexually transmitted disease was independently associated with this infection, while the
variables history of blood transfusion and number of sexual partners showed an
association with a borderline P value (p = 0.05 and p = 0.07, respectively). Viral RNA
was detected in five of the seven anti-HCV positive samples, and the genotype 1,
subtypes 1a (n = 1), 1b (n = 2) and 1a/1b (n = 2) were identified in the study population.
Although the HCV infection prevalence found among recyclable waste collectors in
Goiânia-GO is similar to that observed in local blood donors (1.4%), this population is
in risk to HCV by sexual and parenteral transmission.
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MARINHO, Thaís Augusto. Epidemiologia da infecção pelo vírus da hepatite C em catadores de materiais recicláveis em Goiânia, Goiás. 2012. 103 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2012.