Análise dos resultados sorológico, anatomopatológico e parasitológico de material abortivo para infecções com risco de transmissão vertical com ênfase na toxoplasmose
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2009-11-05
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Universidade Federal de Goiás
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The infection caused by Toxoplasma gondii, Trypanosoma cruzi, Rubella virus, Cytomegalovirus (CMV) and Treponema pallidum, can reach the fetus via the placenta or transamniótica may cause different damage. The severity of the infection or even abortion, depend on the virulence of the strain of microorganism, the immune response of the mother and the period. The aim of this study was to analyze the results of serological, pathological and parasitological material for abortive infections with risk of vertical transmission, with emphasis on toxoplasmosis. They were invited to participate
in the study, women who miscarried and complete or incomplete, attended at two public hospitals in Goiânia, Goiás, between the period June 2008 to June 2009. Were interviewed through a questionnaire and collected blood samples and abortive material. There were immunologic tests for toxoplasmosis, Chagas disease, rubella, cytomegalovirus and syphilis and pathology in cytogenetic. 55% of women were aged 20 to 30 years of age. The majority (68%) had gestational ages ranging from 7-14th weeks. 54.3% of women had completed high school or incomplete. Regarding the
number of abortions, most women (69%) had only one abortion and minority (2.9%) were already in the fourth or fifth abortion. For the analysis of serology, infection with
the risk of vertical transmission was more frequent with the CMV 97.1% positivity and then the rubella 95.2%. Toxoplasmosis has a percentage of 54.3%, Chagas disease by
1.9% and syphilis by 0.95%. The analysis of the biopsy showed that 63.1% showed inflammation and 34% absence of inflammation. Analysis of serological, pathological and parasitological of 105 women, 57 were seropositive for T. gondii. It was observed that 77.1% showed inflammation, detected in pathological examination. None has tested
positive for Polymerase Chain Reaction (PCR) and inoculation in mice. This study demonstrated the high frequency of seropositive for CMV and rubella then toxoplasmosis, Chagas disease and syphilis in our country. The elucidation of the cause of miscarriage is still not routine in our country. These data showed that the prevalence of disease with risk of congenital transmission in patients with spontaneous abortion is important, more research is needed to elucidate the etiology of abortion. Women's health should receive more attention from our managers because primary care is the best
and most efficient path to be followed in order to quality of life for mothers and their future children.
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BARBARESCO, Aline Almeida. Analysis of the results serological, pathological and parasitological of material abortive for infections with a risk of vertical transmission with emphasis on toxoplasmosis. 2009. 117 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Goiás, Goiânia, 2009.