Avaliação clínica, laboratorial e histopatológica do efeito de drogas imunossupressoras na reativação da toxoplasmose crônica em modelo murino com a cepa ME 49 no camundongo BALB/c
Nenhuma Miniatura disponível
Data
2008-03-28
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
This work was evaluated for the potential reactivation of Toxoplasmosis in murine
model similar to human immunosuppression being developed in BALB/c mice, which were 40
days infected with 20 cysts of ME 49 strain of Toxoplasma gondii and after 60 days was
initiated treatment with immunosuppressant drugs, Azathioprine in dosage of 10mg/kg five
times a week in days, Dexametasone in dosage 2.5mg/kg per day per mouse, three times per
week on alternate days, Cortisone acetate in 50mg twice a week in subcutaneous injection of
cortisone acetate alone, or associated with its proper controls. Treatment was continued for
28 days. The use of the Dexametasona or Azathioprine isolated or associated with, a factor
not caused by reactivation of serological tests, clinical or histopathological but associated with
cortisone acetate led to a clinical diagnostic framework of a voluntary recall because of injuries
in epidermal 62.5% of the mice that lot compared to its proper controls, however mortality
was not observed in any of the groups tested
Descrição
Palavras-chave
Citação
ALVES, F. S. A. Avaliação clínica, laboratorial e histopatológica do efeito de drogas imunossupressoras na reativação da toxoplasmose crônica em modelo murino com a cepa ME 49 no camundongo BALB/c. 2008. 84 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2008.