Soroprevalência de COVID-19 e infecção por toxoplasma gondii e fatores associados à ocorrência de lesão renal aguda em pacientes coinfectados
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2022-06-06
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Universidade Federal de Goiás
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Title: Seroprevalence of COVID-19 and Toxoplasma Gondii Infection and Factors
Associated with the Occurrence of Acute Kidney Injury in Coinfected Patients.
Introduction: Coronavirus 2019 (COVID-19) is a severe acute respiratory infection caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), considered one of the greatest
global public health challenges, contributing to a high burden of disease and death. in different age
groups, in addition to those with comorbidities, such as cardiopulmonary and renal diseases,
neoplasms, among others. Faced with the global SARS-CoV-2 pandemic and the high prevalence
of Toxoplasma gondii infection in the population, studying the factors associated with the
occurrence of acute kidney injury in COVID-19 patients, and the seroprevalence of T. gondii
infection becomes necessary, to provide support for adequate initial assessment, improvement in
prognosis and prevention strategies for the control of Covid-19 and Toxoplasmosis. Objective: To
epidemiologically characterize a group of inpatients in an intensive care unit with COVID-19,
coinfected with T. gondii. Methods: Analytical cross-sectional study, with an analytical approach,
carried out in a public university hospital in Goiânia - Goiás. A total of 314 patients participated in
the study, admitted to an intensive care unit, diagnosed with COVID-19 by the RT-PCR or RTLAMP
methods, and serology for toxoplasmosis by the IgG ELISA method, and IgM
Results: A study of seroprevalence of toxoplasmosis in patients with COVID-19 was not
identified. Seropositivity was found for the IgG class: 78.1%, and IgM/IgG: 3.5%. In the sample,
there was a predominance of males, ie (55.4%). Most of them are people aged 60 years or older
(49.7%), living in Goiás (98.5%), which represents the highest frequency of hospitalizations
among elderly people. 20-39 years (p=0.014) and 40-59 years (p=0.027) were protective factors
for toxoplasmosis in patients with COVID-19. 88.5% of mixed race, living with someone (65.6%),
retired (38.6%), with income of less than 2 years minimum (51.8%), with incomplete elementary
school (53.4%) and living with 3 residents (52.3%). It is observed that there is an inverse trend, the
higher the level of education, the lower the prevalence of toxoplasmosis. For behavioral habits
(alcohol consumption, smoking, use of illicit drugs), no statistically significant was found. As for
the origin of origin (67.9%) from a Basic Health Unit. As comorbidities prevail, systemic arterial
hypertension, diabetes mellitus, obesity, COPD, neoplasms, and clinical manifestations, fever,
asthenia, myalgia and headache. As for death, 158.5 % died. There were no significant differences
between patients and patients who were discharged or downloaded. There were no significant
results associating Acute Renal Failure (AKI) with toxoplasmosis in patients with COVID-19.
Patients with COVID-19 and evidenced the presence of kidney disease 9 who are hospitalized in
patients, evolution of the clinical condition to hemodialysis (P) No statistically significant results
were identified that show associations between variables, a factor that demands further
investigation. Conclusions: The results of the study show a elevated prevalence of toxoplasmosis
patients at susceptibility to COVID-19 (77%), suggesting a high susceptibility of patients with
developmental disease, evidencing opportunistic opportunities. Individuals over 60 years of age
are at greater risk of being co-infected. There were no ARI, associations between toxoplasmosis
infection in patients with COVID-19 and patients with COVID-19, who have more kidney
problems and consequently progress to hemodialysis. Relevance and impact: It is valid, due to
the high frequency of Toxoplasmosis and COVID-19 cases and association with renal impairment
of patients who evolved with the need for renal replacement therapy, it is important to reflect and
understand the severity of the disease, establish preventive, diagnostic and effective therapies in a
more targeted and faster way, as well as preventive measures for effective decision making.
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SILVA, W. G. Soroprevalência de COVID-19 e infecção por toxoplasma gondii e fatores associados à ocorrência de lesão renal aguda em pacientes coinfectados. 2022. 104 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2022.