Estudo da porosidade de comprimidos de Cloridrato de Propranolol a partir do processamento de imagens de microscopia eletrônica de varredura por elétrons retroespalhados
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2021-12-07
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Universidade Federal de Goiás
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The porosity of solid pharmaceutical forms plays a fundamental role in the drug's disintegration the dosage form and consequently in the bioavailability of the active, ensuring its therapeutic action in the desired time, in addition, the porosity influences other aspects such as the mechanical strength of the tablet. Understanding and having methods to study and manipulate the porosity of pills is a crucial factor to have a quality pharmaceutical form. Objectives: Thus, the objective of this work was to study the porosity of Propranolol Hydrochloride tablets from 5 (five) laboratories by processing images obtained in a scanning electron microscope and to correlate these results with dissolution studies and the composition of each tablet. Methodology: The tablets were characterized by thermal techniques, Scanning Differential Calorimetry (DSC) and Thermogravimetry (TGA), and were submitted to hardness, friability and dissolution tests. Electron backscatter SEM images were obtained and processed in order to obtain an estimate of the surface and fracture porosity. Results and discussion: The tablets showed variations in their internal porosity and fracture, all had friability and hardness data that meet current regulatory standards, for the dissolution study, all laboratories presented data within the acceptance criteria of regulatory standards. Conclusions: Through the processing of scanning electron microscopy images obtained from propranolol hydrochloride tablets, it was possible to estimate the surface and fracture porosity of these tablets, thus, this technique is shown as an alternative for the study of the porosity of solid dosage forms (tablets) , being possible to observe the morphology and characteristics of the pores.
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CAMARGO, H. S. Estudo da porosidade de comprimidos de Cloridrato de Propranolol a partir do processamento de imagens de microscopia eletrônica de varredura por elétrons retroespalhados. 2021. 84 f. Tese (Doutorado em Inovação Farmacêutica em Rede) - Universidade Federal de Goiás, Goiânia, 2021.