Sítios implantáveis da maxila e mandíbula: correlação entre aspectos clínico-radiográficos e histomorfométrico-moleculares.
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2011-03-04
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Universidade Federal de Goiás
Resumo
The study of bone microarchitecture and its molecular aspects may provide new information for better understanding of "bone quality". Histomorphometry is a recommended reference method for bone-dimensional analysis. At the molecular level, possible changes in the process of resorption and bone formation has not been studied in different patterns of bone "normal." Objective: To analyze the correlation between clinical, radiographic and histomorphometric bone-molecular sites for dental implants in humans. Methods: The sample consisted of 44 sites of 32 volunteers implantable. These sites were classified according to three different methods: a classification based only on periapical and panoramic images (PP), the classification of Lekholm and Zarb, based on methods of diagnostic imaging in conjunction with the tactile perception of the surgeon during surgery and classification of Lindh. The bone specimens were removed with the use of trephine during the first drilling site for placement of dental implants. The samples were subjected to staining with hematoxylin-eosin and histomorphometric analysis to obtain the following histomorphometric parameters: trabecular thickness (Tb.Th), trabecular number, bone volume fraction (BV / TV), trabecular bone surface area by bone volume (BS / BV), bone surface fraction and trabecular separation (Tb.Sp). We also made the technique for analysis of proteins immunoistoquímica RANK, RANKL, OPG and osteocalcin (OC) in samples of bone tissue. Results: Rankings PP & L and Z correlated with BV / TV, BS / BV, Tb.Th and Tb.Sp. The classification of Lindh did not correlate with any histomorphometric parameter. L & Z show differences between types when compared to bone BV / TV, BS / BV, Tb.Th and Tb.Sp. We found a weak correlation between ratings PP / L & Z and the expression of regulators of bone metabolism (RANK, RANKL, OPG and OC). Conclusions: It may be that the subjective ratings conculir types of bone are influenced by aspects of histomorphometry and the regulatory molecules of bone remodeling seems not to exert influence in the morphology of the maxilla and mandible.
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PEREIRA, Andrea de Castro. Sites implantable maxilla and mandible: correlation between clinical, radiographic and histomorphometric-molecular.. 2011. 77 f. Dissertação (Mestrado em Ciência da Saúde) - Universidade Federal de Goiás, Goiânia, 2011.