Estudo do efeito antinociceptivo e/ou anti-inflamatório das folhas de Spiranthera odoratissima A. St.-Hil. (Manacá). -Possível mecanismo envolvido
Data
2010-08-30
Autores
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Universidade Federal de Goiás
Resumo
Spiranthera odoratissima A. St.-Hil. is popularly known as Manacá and it is a native
plant of the Brazilian Savanna Cerrado, and it can be found in the states of Mato
Grosso, Goiás, Minas Gerais and Bahia. In the folk medicine this plant is used as an
appetite stimulant and to treat rheumatism, abdominal pain, headache, muscle pain,
stomach and liver dysfunction, kidney infections and urinary retention. The
hydromethanolic fraction was obtained from the ethanolic extract of Spiranthera
odoratissima leaves. According to phytochemical screening this fraction contains
anthraquinones, tannins, flavonoids and coumarins. This fraction showed
antinociceptive activity in the acetic acid-induced writhing method and the
involvement of central antinociceptive mechanisms was discarded with the hot plate
test, since the reduction in the latency to pain was not observed. The major subfraction
isolated from the hydromethanolic fraction (sub-Fr10-28) showed antiinflammatory
activity in different methodologies. Both hydromethanolic fraction and
sub-Fr10-28 contain tannins able to inhibit the activity of phospholipase A2 enzyme,
and subsequently inhibiting the production of arachidonic acid and preventing the
production of eicosanoids such as prostaglandins, thromboxanes and leukotrienes by
lipoxygenase and cyclooxygenase enzymes participation. These eicosanoids are
important mediators for the maintenance of inflammatory process. Concluding, the
analgesic effect of this plant may be due to an anti-inflammatory action, and this antiinflammatory
action could be the result from the blockage of the phospholipase A2
enzyme.
Descrição
Palavras-chave
Spiranthera odoratissima St.-Hil. , antinociceptiva , antiinflamatória , fosfolipase A2 , planta medicinal , Spiranthera odoratissima A. St.-Hil. , antinociceptive , anti-inflammatory , phospholipase A2 , medicinal plant , 1. Spiranthera odoratissima A. St.-Hil 2.
Antinociceptiva 3. Planta - Anti-inflamatória 4. Planta
medicinal
Citação
BARBOSA, Daniela Borges Marquez. Study of analgesic effect and / or anti-inflammatory
Leaves Spiranthera odoratissima A. St.-Hil. (Manacá).
-Possible mechanism involved. 2010. 64 f. Dissertação (Mestrado em Ciências da Saúde - Farmácia) - Universidade Federal de Goiás, Goiânia, 2010.