2016-09-062015-12-15PEIXOTO, L. F. Avaliação do efeito protetor do extrato bruto hidroalcoólico das folhas de Eugenia dysenterica DC. sobre a neurotoxicidade induzida pelo alumínio. 2015. 62 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/6134incidence of neurodegenerative disease (ND) is increasing with the world population aging. Among them, Alzheimer's disease (AD) is the most common of dementia in the elderly population. The AD has been linked to oxidative stress resulting in neurodegenerative disorders, such as the impairment of the antioxidant and cholinergic systems. AChE inhibitors drugs are a treatment option used for AD. However, until now, the drug treatment only temporary attenuates the AD symptoms and new drug targets, as the medicinal plants, are necessary for a better treatment of this disease. Eugenia dysenterica DC (Myrtaceae), popularly known as cagaita, is a native plant from the Cerrado region of Brazil. It is used in the folk medicine to treat diarrhea, jaundice and diabetes. Data from literature reported the presence of phenolic compounds, such as flavonoids and tannins, in the leaves of E. dysenterica. Thus, the aim of this study was to evaluate the neuroprotective effect of crude hydroalcoholic extract of E. dysenterica leaves (HEED), using a model of neurotoxicity induced by aluminium in mice and that causes similar cellular alterations of that observed in the Alzheimer’s disease. The results showed the HEED increased the mice performance in the passive avoidance test, showing the reversion of the cognitive damage promoted by aluminium. In addition, the HEED reduced the neuronal lipid peroxidation and restored the activity of superoxide dismutase (SOD), catalase (CAT) and acetylcholinesterase (AChE) enzymes in mice brain. The histological analysis showed the HEED decreased the incidence of neuronal death by necrosis. Taken together, the results here obtained suggest that the antioxidant properties of HEED are the responsible for its neuroprotective effect.application/pdfAcesso AbertoEugenia dysenterica DC.AlumínioEstresse oxidativoNeurodegeneraçãoDoença de AlzheimerDefesas antioxidantesDefesas antioxidantesAtividade anticolinesterásicaAluminiumOxidative stressNeurodegenerationAlzheimer's diseaseAntioxidant defensesaAnticholinesterase activityCIENCIAS BIOLOGICAS::FARMACOLOGIADissertação