2014-07-292012-06-052011-11-18http://repositorio.bc.ufg.br/tede/handle/tde/1744This dissertation aimed to study the breast cancer with emphasis on the molecular subtypes. In the theoretical context, important aspects on the subject were reviewed, including prognostic aspects, predictive factors and molecular markers used in the classification by immunohistochemistry. In the practical context, the prevalence of the molecular subtypes was evaluated in a series of patients with invasive ductal breast carcinoma, using two different panels of classification by immunohistochemistry, with and without the use of proliferation marker Ki-67. We evaluated the agreement between the results obtained by the two classification models, correlating the subtypes found with the clinicopathological characteristics of tumors. Two papers were prepared, a review article, from the MEDLINE/ PubMed, LILACS and SciELO database with relevant topics about the molecular subtypes of the breast cancer and their classification by immunohistochemistry; and an original article, in which a study with 234 cases of invasive ductal carcinoma of the breast was conducted, according to the objectives previously mentioned. A significant change in the percentage of luminal tumors was observed with the use of the Ki-67, and a significant correlation with the histological grade.application/pdfAcesso AbertoNeoplasias da mamaclassificaçãoprognósticoimunoistoquimicabreast neoplasmsclassificationprognosis immunohistochemistryCNPQ::CIENCIAS DA SAUDEDissertação