2023-04-132023-04-132021BIASOTTI, Gabriel Gustavo de Albuquerque et al. 2D quantitative imaging of magnetic nanoparticles by an ac biosusceptometry based scanning approach and inverse problem. Sensors, Basel, v. 21, e7063, 2021. DOI: 10.3390/s21217063. Disponível em: https://www-ncbi-nlm-nih.ez49.periodicos.capes.gov.br/pmc/articles/PMC8587841/pdf/sensors-21-07063.pdf. Acesso em: 11 abr. 2023.e- 1424-8220http://repositorio.bc.ufg.br/handle/ri/22330The use of magnetic nanoparticles (MNPs) in biomedical applications requires the quantitative knowledge of their quantitative distribution within the body. AC Biosusceptometry (ACB) is a biomagnetic technique recently employed to detect MNPs in vivo by measuring the MNPs response when exposed to an alternate magnetic field. The ACB technique presents some interesting characteristics: non-invasiveness, low operational cost, high portability, and no need for magnetic shielding. ACB conventional methods until now provided only qualitative information about the MNPs’ mapping in small animals. We present a theoretical model and experimentally demonstrate the feasibility of ACB reconstructing 2D quantitative images of MNPs’ distributions. We employed an ACB single-channel scanning approach, measuring at 361 sensor positions, to reconstruct MNPs’ spatial distributions. For this, we established a discrete forward problem and solved the ACB system’s inverse problem. Thus, we were able to determine the positions and quantities of MNPs in a field of view of 5 5 1 cm3 with good precision and accuracy. The results show the ACB system’s capabilities to reconstruct the quantitative spatial distribution of MNPs with a spatial resolution better than 1 cm, and a sensitivity of 1.17 mg of MNPs fixed in gypsum. These results show the system’s potential for biomedical application of MNPs in several studies, for example, electrochemical-functionalized MNPs for cancer cell targeting, quantitative sensing, and possibly in vivo imaging.engAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/Magnetic nanoparticlesInverse problemQuantitative imagingAC BiosusceptometryArtigohttps://doi.org/10.3390/s21217063