2021-01-262021-01-2620081-MATOS, Lecia G. de et al. Anti-inflammatory, antinociceptive, and sedating effects of lafoensia pacari aqueous extract. Pharmaceutical Biology, London, v. 46, n. 5, p. 341-346, 2008.1388-0209e- 1744-5116http://repositorio.bc.ufg.br/handle/ri/19308The acetic acid–induced abdominal writhing, the tail flick, and the croton oil–induced mouse ear edema tests were used to study the anti-inflammatory effects of the aqueous extract from Lafoensia pacari A. St.-Hil. (Lythraceae) stem bark. Pentobarbital-induced sleeping timewas used to study the central nervous system depressant effect of the extract. The aqueous extract caused a dose-dependent inhibition of acetic acid–induced abdominal writhing and ear edema formation and produced a significant (p < 0.05) dose-related increase in the duration of sleep. The results suggest that Lafoensia pacari stem bark contains compounds with antiinflammatory, analgesic, and central depressant actions.engAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/Analgesic activityAnti-inflammatory effectCentral depressant actionsLafoensia pacariEar edemaLythraceaeArtigo10.1080/13880200801887799