2025-02-112025-02-112016SILVA, Thaísa C. et al. Prevalence and lethality among patients with histoplasmosis and AIDS in the Midwest Region of Brazil. Mycoses, Berlin, v. 60, n. 1, p. 59-65, 2017. DOI: 10.1111/myc.12551. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/myc.12551. Acesso em: 10 fev. 2025.0933-7407e- 1439-0507https://onlinelibrary.wiley.com/doi/10.1111/myc.12551Histoplasmosis is a systemic mycosis that is considered an important public health problem. In this work, we performed a descriptive, observational, cross-sectional and retrospective study with a secondary data analysis of medical records from 2000 to 2012 at a tertiary hospital. The study sample consisted of 275 patients with laboratory-confirmed Disseminated Histoplasmosis (DH)/AIDS. The results showed that the prevalence of DH associated with AIDS was 4.4%. The majority of patients were young adult men with fever in 84.2%, cough in 63.4%, weight loss in 63.1%, diarrhoea in 44.8% and skin manifestations in 27.6% of patients. In the overall cohort, the CD4 counts were low, but not significantly different in survivors and non-survivors. Higher levels of urea and lower levels of haemoglobin and platelets were observed in non-survivor patients (<.05). The global lethality was 71.3% (196/275). The results with high prevalence and lethality highlight the need to adopt measures to facilitate early diagnosis, proper treatment and improved prognosis.engAcesso RestritoArtigo10.1111/myc.12551