2023-12-192023-12-192023SANTOS NETO, Antônio Gomes dos et al. Host-guest assembly based on γ-cyclodextrin-functionalized multiwalled carbon nanotubes for Rutin electrochemical sensing. Electroanalysis, Weinheim, v. 35, n. 5, e202200390, 2022. DOI: 10.1002/elan.202200390. Disponível em: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202200390. Acesso em: 12 dez. 2023.e- 1521-4109https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202200390Here, we report multiwalled carbon nanotubes (MWCNTs) functionalized with γ-cyclodextrins (γCD) as a novel electrochemical strategy for Rutin determination, showing superior performance than β-cyclodextrins (βCD) modified MWCNTs, suggesting an adequate environment for host-guest interactions. Under optimized conditions, the sensor showed a linear range of 39–975 nmol L−1 and a limit of detection of 7 nmol L−1. When tested with quercetin, catechin, and caffeine, the platform presented high selectivity with an interference response <10 %. The method was employed to quantify Rutin in spiked pharmaceutical and herbal extracts, providing recovery of 93–98.4 %. Also, HPLC-PDA confirmed the method‘s accuracy.engAcesso RestritoSupramolecular chemistryMulti-walled carbon nanotubesRutinHost-guestSquare wave voltammetryFlavonoidsPharmaceutical compoundsArtigo10.1002/elan.202200390