2023-05-192023-05-192019FERNANDES, Aline R.; BERNARDO, Ricardo A.; CARVALHO, Thays C. de; VAZ, Boniek G.; CHAVES, Andréa R. Graphene oxides coated paper as a substrate to paper spray ionization mass spectrometry for creatinine determination in urine samples. Journal of the Brazilian Chemical Society, Campinas, v. 30, n. 5, p. 1074-1081, 2019. DOI: 10.21577/0103-5053.20190007. Disponível em: https://jbcs.sbq.org.br/default.asp?ed=284. Acesso em: 17 maio 2023.e- 1678-47900103-5053http://repositorio.bc.ufg.br/handle/ri/22579Paper spray ionization (PSI) is a promising analytical tool for direct analysis in mass spectrometry (MS). However, this technique usually uses chromatographic paper, which rarely accomplishes a stable MS signal and could vary with the sample matrix effect. In the present study, the application of graphene oxides (GO) was scrutinized as modifier paper substrate for PSI-MS methods. The developed substrate efficiency was evaluated towards creatinine determination in urine samples. The GO-PSI-MS developed method for creatinine in urine samples showed linearity in the range of 0.1 to 3.4 ppm with R2 = 0.9991. The precision was evaluated and the values were between 1.1 to 6.8% and the accuracy above 96.8%. The limit of quantification (LOQ) and limit of detection (LOD) were 0.05 and 0.17 ppm, respectively. The GO-PSI developed was compared to conventional chromatographic paper for PSI-MS methods, and the results showed that the modified paper with GO bolsters method linearity, precision, and LOQ values.engAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/Paper spray ionizationGraphene oxideCreatinineUrineMass spectrometryArtigohttps://dx.doi.org/10.21577/0103-5053.20190007