2025-06-042025-06-042018-04TORRES, B. B. J. et al. Dantrolene e células-tronco mesenquimais promovem melhora funcional em ratos Wistar com trauma espinhal agudo. Pesquisa Veterinária Brasileira, Seropédica, v. 38, n. 4, p. 703–709, 2018. DOI: 10.1590/1678-5150-PVB-5165. Disponível em: https://www.scielo.br/j/pvb/a/WhCRmHrxsSPC5DSJWVpBcNc/?lang=pt. Acesso em: 02 jun. 2025.0100-736Xe- 1678-5150http://repositorio.bc.ufg.br//handle/ri/27663This study aimed to evaluate the effects of dantrolene (DAN) and mesenchymal stem cells (MSCs) in acute spinal cord injury (SCI). Sixty Wistar rats were divided into groups MSCs, MSCs + DAN, DAN, trauma and placebo (TP) and no trauma and placebo (STP). Laminectomy was performed at T12 level in all animals, followed by a weight-drop model of SCI, except for the STP group. An hour later, the MSCs + DAN and DAN groups received 10mg/kg of DAN. After seven days, the MSCs and MSCs + DAN groups received 1x106 cells intravenously. Behavioral tests were performed to assess functional recovery for 28 days. Traumatized animals showed paraplegia. There was a significant improvement in groups MSCs, DAN and MSCs + DAN compared to TP (p<0.05). It was concluded that DAN and MSCs for the treatment of SCI in rats have neuroprotection effect and promote functional neurological improvement.porAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/DantroleneCélulas-tronco mesenquimaisRecuperação funcionalRatos WistarTrauma espinhal agudoTraumatismos da medula espinalTerapia celularBloqueadores dos canais de cálcioEscala de avaliação comportamentalRatosMesenchymal stem cellsFunctional improvementWistar ratsSpinal cord injuryCellular therapyCalcium channel blockersBehavior rating scaleRatsArtigo10.1590/1678-5150-PVB-5165