2025-06-112025-06-112019FRAIHA, Rafael Ovando. Stress conditions induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A. Revista da Sociedade Brasileira de Medicina Tropical, Rio de Janeiro, v. 52, e20180001, 2019. DOI: 10.1590/0037-8682-0001-2018. Disponível em: https://www.scielo.br/j/rsbmt/a/3V8BtQvkGZvyDdkdQ35QtbG/?lang=en. Acesso em: 6 jun. 2025.0037-8682e-1678-9849http://repositorio.bc.ufg.br//handle/ri/27740Introduction: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. Methods: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. Results: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. Conclusions: These findings highlight the role of host stress in the virulence of S. epidermidis.engAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/PersistenceStarvationVirulenceArtigo10.1590/0037-8682-0001-2018