2024-12-102024-12-102022FERREIRA, Tathiany Jéssica et al. Dietary intake is associated with miR-31 and miR-375 expression in patients with head and neck squamous cell carcinoma. Nutrition and Cancer, Philadelphia, v. 74, n. 6, p. 2049-2058, 2022. DOI: 10.1080/01635581.2021.1990972. Disponível em: https://www.tandfonline.com/doi/full/10.1080/01635581.2021.1990972. Acesso em: 9 dez. 2024.0163-5581e- 1532-7914https://www.tandfonline.com/doi/full/10.1080/01635581.2021.1990972MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. Nutrients are known to influence miRNA expression; however, this association is poorly explored in HNSCC. This work aimed to identify associations between dietary intake and the expression of miR-31 and miR-375 in patients newly diagnosed with HNSCC. The expression of miR-31 was positively associated with the consumption of iron (β = 16.65) and vitamin C (β = 0.37), and inversely associated with total sugar (β = −0.88), cholesterol (β= −0.23), vitamin B9 (β= −0.37) and zinc (β = −5.66) intake. The expression of miR-375 was positively associated with the consumption of selenium (β = 1.52), vitamin C (β = 0.17) and vitamin D (β = 13.01), and inversely associated with the consumption of added sugar (β = −0.49), phosphorus (β= −0.27) and vitamin B12 (β = −10.80). Our findings showed important associations between dietary intake and miR-31 and miR-375 expression in HNSCC, offering possible directions for further studies investigating how nutrients interfere with carcinogenesis.engAcesso RestritoArtigo10.1080/01635581.2021.1990972