2025-07-252025-07-252022SOARES, Giovana Alice Sampaio; MORAES, Felipe Augusto de Sousa; BARBOSA, Mônica Santiago. Relação entre a infecção por Helicobacter pylori e doenças hematológicas: uma revisão integrativa. Clinical and Biomedical Research, Porto Alegre, v. 42, n. 2, p. 176-185, 2022. DOI: 10.22491/2357-9730.114541. Disponível em: https://seer.ufrgs.br/hcpa/article/view/114541. Acesso em: 23 jul. 2025.2357-9730https://repositorio.bc.ufg.br//handle/ri/28126Helicobacter pylori is a gram-negative bacterium that has been associated with gastric diseases since 1984. Since the 1990s, there have been increasing reports indicating that the infection may also be associated with extragastric manifestations. This integrative review aimed to investigate the evidence on the relationship between H. pylori and hematological diseases, specifically iron deficiency anemia (IDA) and idiopathic thrombocytopenic purpura (ITP). Databases were searched for the keywords “Helicobacter pylori,” “extragastric diseases,” “hematologic diseases,” “iron deficiency anemia,” and “idiopathic thrombocytopenic purpura” in English, Portuguese, and Spanish, combined with the boolean operator “AND.” The search yielded 1,964 studies. After reading the titles, only 85 met the inclusion criteria. Sixty-two studies were selected for full-text reading after exclusion of duplicates and abstract analysis. Finally, 27 studies were included in this review. Thirteen studies addressed IDA, among which 77% found an association with H. pylori; whereas 14 studies addressed ITP, among which 93% found a relationship with H. pylori. There is strong evidence supporting the association between hematologic diseases and H. pylori. Further studies are needed to elucidate the mechanisms involved in this relationship, contributing to more effective prevention, diagnosis, and treatment. Keywords: Helicobacter pylori; Bacterial infections; Hematologic diseases; Anemia; Iron-deficiency; Purpura thrombocytopenic idiopathicporAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/Helicobacter pyloriInfecções bacterianasDoenças hematológicasAnemia ferroprivaPúrpura trombocitopênica idiopáticaArtigo10.22491/2357-9730.114541