2017-07-242017-07-242008-12MATOS, Moema Pacheco Chediak; MIGUEL, Marina Pacheco; MOURA, Veridiana Maria Brianezi Dignani; SOBESTIANSKY, Jurij; BRITO, Luiz Augusto Batista. Avaliação histológica de fígado, rim, tireóide, paratireóide e osso de suínos em terminação submetidos a diferentes dietas. Ciência Animal Brasileira, Goiânia, v. 9, n. 4, p.1128-1137, out./dez. 2008. Disponível em: < https://www.revistas.ufg.br/vet/article/view/1573/4377>.e- 1809-6891http://repositorio.bc.ufg.br/handle/ri/12186The present experiment aimed to evaluate histological changes in hepatic, renal, thyroid, parathyroid and metacarpian bone tissues of pigs submitted to diets without micro minerals and vitamins, reduced inorganic phosphorus levels and phytase addition in two restriction times. Forty eight 105-days old (66.15±0.14 kg) female pigs received experimental diets with corn, soybean and wheat meal. The animals were randomly distributed in six groups: standard diets (T1); composed of corn, soybean meal and wheat meal; standard ration without micro mineral and vitamin supplement (T2); T2 ration with phytase (T3); T2 ration reducing 1/3 of inorganic phosphorus with phytase (T4); T2 ration reduced 2/3 of inorganic phosphorus with phytase (T5); and T2 ration with complete reduction of inorganic phosphorus with phytase (T6). The experiment was carried out in two phases: Phase 1. 24 animals, 35 days of restriction and slaughter at 150 days of age (106.65 kg), and Phase 2, 24 animals, 60 days of restriction and slaughter at 175 days of age (123.87 kg). At slaughter, samples of liver, kidney, thyroid, parathyroid and metacarpian bone were collected from all animals. The samples were fixed in 10% buffered formaldehyde and stained by hematoxilin and eosin (HE). The Mallory’s trichrome stain was used in bone sections. Kidney histopathological evaluation showed interstitial nephritis in 37 animals (77%). Mononuclear inflammatory infiltrated was observed focally on liver of 15 animals (31.25%). Treatments didn’t promote histopathological changes in thyroid and parathyroid glands. The metacarpian bone microscopy showed low osteochondrosis in animals of different treatments and phases. However, in experimental time, clinic signs of bone metabolic disease and osteochondrosis were not verified. Phytase addition was efficient to provide phytic phosphorus in the diet, since no macro or microscopic lesions characterizing phosphorus deficiency in the bone samples were present.porAcesso AbertoAlterações histológicasFitaseRestrição de fósforoVitaminasMicromineraisHistopathologic changesMicro mineralsPhytasePhosphorus restrictionVitaminsArtigo