2025-01-202025-01-202019BORGES, Moara Alves Santa Bárbara et al. False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia. Medical Mycology Case Reports, Amsterdam, v. 26, p. 64-66, 2019. DOI: 10.1016/j.mmcr.2019.10.009. Disponível em: https://www.sciencedirect.com/science/article/pii/S2211753919300909?via%3Dihub. Acesso em: 17 jan. 2025.e- 2211-7539http://repositorio.bc.ufg.br//handle/ri/26419The detection of cryptococcal capsular antigen (CrAg) is very sensitive and specific, however false-negative results have been reported, mostly in cerebrospinal fluid. We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative result is possible. Careful clinical evaluation and close follow-up are relevant.engAcesso Abertohttp://creativecommons.org/licenses/by-nc-nd/4.0/CryptococcosisAIDSFungal antigensFalse negative reactionProzone effectArtigo10.1016/j.mmcr.2019.10.009