FANUT - Trabalhos de Conclusão de Curso

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Navegando FANUT - Trabalhos de Conclusão de Curso por Autor "Crespo, Adriana de Moraes Costa"

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    Perfil inflamatório de pacientes com Colite Ulcerativa em uso de cúrcuma longa
    (Universidade Federal de Goiás, 2017-06-26) Santos, Ludimila Ribeiro dos; Santos, Luthiana da Paixão; Nagib, Patrícia Resende Alo; Nagib, Patrícia Resende Alo; Mortoza, Andréa Sugai; Crespo, Adriana de Moraes Costa
    Aim: To evaluate the possible effects of Curcuma longa on the inflammatory markers of patients with Ulcerative Colitis. Methodology: The work was double-blind, placebo-controlled, clinical trial conducted at the Hospital das Clinicas de Goiânia (HC/EBSERH/UFG) in a period of 8 weeks. The patients ingested 3 capsules per day of dried extract of curcuma. The sample consisted of 8 patients in the active phase of ulcerative colitis, of both sexes, aged 18 years or older. The cytokines IL-10, IL-6 and TNF-α plasmatic levels was verified by the ELISA method, before and after the curcuma treatment. The test group (n = 4) received 3 capsules per day, containing 500mg dry extract of Curcuma longa and the placebo group (n = 4), received cellulose in the same amount. Results: Only two participants reduced TNF-α levels (pre: 57 pg/ml and post: 30 pg/ml), (pre: 11pg/ml and post, 9 pg / ml) (pre:1 pg/ml and pos: 10 pg/ml) and (pre: 8 pg/ml and pos: 28 pg / ml). In relation to IL-6, three patients presented increased plasma levels (pre: 0.104 pg/ml and post: 0.108 pg/ml), (pre: 0.123 pg/ml and post: 0.209 pg/ml) and (pre: 0.118 pg/ml and post: 0.151 pg/ml) and one patient had a significant reduction (pre: 0.289 pg / ml and post: 0.084 pg / ml). In relation to IL-10, three patients presented a slight increase in the concentration of this cytokine (pre: 0.108 pg/ml and post: 0.109 pg/ml), (pre: 0.099 pg/ml and post: 0.116 pg/ml): 0.192 pg/ml and post: 0.0.098 pg/ml). One participant presented a significant reduction of this cytokine (pre: 0.192 pg/ml and post: 0.098 pg/ml). However, none of these data were statistically significant, probably due to the low number of participants and non-control variables, such as: diet, lifestyle, time of exposure to the disease, genetics and dose of mesalazine. Conclusion: This study did not prove that Curcuma longa is able to reduce the inflammation of patients with ulcerative colitis, however, new studies should be performed by analyzing other variables.