FM - Artigos publicados em periódicos

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Navegando FM - Artigos publicados em periódicos por Autor "Albuquerque, Zair Benedita Pinheiro de"

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    Controle da qualidade em citopatologia cervical: revisão da literatura
    (2007) Tavares, Suelene Brito do Nascimento; Amaral, Rita Goreti; Manrique, Edna Joana Cláudio; Souza, Nadja Lindany Alves de; Albuquerque, Zair Benedita Pinheiro de; Zeferino, Luiz Carlos
    Cervical cytopathology is an important tool for the detection of precursor lesions of cervical cancer, which are still treatable at that stage, thus resulting in a significant decrease in mortality. However, cervical cytopathology has drawbacks, with the false-negative rate varying from 2 to 50%. False-negative results are mainly due to errors in sample collection, examination, and interpretation. The ultimate objective of routine internal and external quality control in laboratories is to improve the test's diagnostic performance, evaluate screener performance, and identify causes of sample collection errors. Internal quality control can be performed regularly and involves monitoring the sample adequacy, duration of the examination, screener workload, hierarchical review of smears, and review of negative smears. Internal quality control can also include analysis of the cytology/histology correlation, review of previous exams, monitoring of statistics on frequency of lesions and sample adequacy, and deliberate inclusion of abnormal smears in routine exams. Continuing education, personnel training, and periodic proficiency exams are strategies that should be adopted. Random or 100% review of smears, rapid review, and detailed reviews are methods that have advantages and disadvantages for the detection of false-negative results. It is the laboratory's task to define the best strategy for internal quality control that will lead to improvement in technical procedures and consequently in the quality of the service provided by cytopathology laboratories.
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    A revisão rápida de 100% é eficiente na detecção de resultados falsos-negativos dos exames citopatológicos cervicais e varia com a adequabilidade da amostra: uma experiência no Brasil
    (2007) Manrique, Edna Joana Cláudio; Tavares, Suelene Brito do Nascimento; Souza, Nadja Lindany Alves de; Albuquerque, Zair Benedita Pinheiro de; Zeferino, Luiz Carlos; Amaral, Rita Goreti
    PURPOSE: to evaluate the effi ciency of the 100% rapid rescreening in the detection of false-negative results and to verify whether the results vary according to the adequacy of the sample and the woman’s age group. METHODS: to evaluate the effi ciency of the rapid rescreening, the 5,530 smears classifi ed as negative by the routine screening, after being submitted to the rapid rescreening of 100%, were compared with the rescreening of the smears on the basis of clinical criteria and 10% random rescreening. For statistical analysis, the variables were evaluated descriptively and the χ 2 test and the Cochran-Armitage test were applied to compare results. RESULTS: of the 141 smears identifi ed as suspicious according to the rapid rescreening method, 84 (59.6%) cases were confi rmed in the fi nal diagnosis, of which 36 (25.5%) were classifi ed as atypical squamous cells of undetermined signifi cance, fi ve (3.5%) as atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion, 34 (24.1%) as low-grade squamous intraepithelial lesion, six (4.3%) as high-grade squamous intraepithelial lesion, and three (2.1%) as atypical glandular cells. Of the 84 suspect smears confi rmed in the fi nal diagnosis, 62 (73.8%) smears were classifi ed as adequate and 22 (26.2%) as adequate but with some limitation, but no signifi cant difference was observed with the woman’s age. CONCLUSIONS: the results of this study show that rapid rescreening is an effi cient option for internal quality control for the detection of false-negative cervical smear results. In addition, it should be noted that rapid rescreening performed better when the sample was classifi ed as adequate for analysis; however, it did not vary according to the woman’s age group.